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Dr. Varun Dhir
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Designation : Associate Professor |
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Department : INTERNAL MEDICINE |
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Educational
Qualification |
| Graduation
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MBBS from AIIMS in year 2002
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| Post
Graduation |
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MD medicine from AIIMS in year 2004
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| Other
Qualification.(1) |
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DM Clinical Immunology Rheumatology from SGPGI in year 2009
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Area of Interest |
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Area Of Interest |
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My research work focusses on rheumatoid arthritis the prototypic and most common rheumatic disease which has an autoimmune and genetic background. I have worked on the pharmacology and pharmacotherapeutics of the conventional DMARD Methotrexate. We have looked at intracellular methotrexate polyglutamate levels in RBCs by High performance liquid chromatography and found higher triglutamate levels in patients with adverse effects. In addition, we have looked at the T-helper subtype repertoire in rheumatoid arthritis and its modulation by methotrexate, in which we found a predominant effect on T-cytotoxic CD8 cells producing interferon-gamma. Our team has worked on looking at the relevance of methotrexate associated adverse effects, supplementation with different doses of folic acid, levels of methotrexate polyglutamates in RBCs and T helper and T cytotxic cells cytokine defined subsets in peripheral blood. |
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Research & Projects |
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Projects |
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1.Change in neutrophil functions on treatment with methotrexate in rheumatoid arthritis. Started 28 Dec 2017 (till Dec 2020), Sponsored by Department of Health and Research, GOI 2.CD8 Subsets In Rheumatoid Arthritis And Change With Methotrexate Therapy. Started January 2019 (till 2021). Sponsored by Science and Engineering Research Board, Department of Science and Technology, GOI 3 Measurement of methotrexate polyglutamates inrheumatoid arthritis and its relationship to adverse effects and efficacy 2013-2017. Sponsored by Department of Biotechnology, GOI Published Sandhu A, Dhir V et al. High Methotrexate Triglutamate Level Is anIndependent Predictor of Adverse Effects in Asian Indian Rheumatoid ArthritisPatients-A Preliminary Study. Ther Drug Monit. 2017 Apr;39(2):157-163. 4. Frequencies of circulating T helper subsets in rheumatoid arthritis and change on treatment with methotrexate. 2015-18 Sponsored by Department of Science and Technology Published Sandhu A, Dhir V et al. Clinical Rheumatology Methotrexate preferentially affects Tc1 and Tc17 subset of CD8 T lymphocytes. Clin Rheumatol. 2018 |
Departmental / P.G.I.
Projects |
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| The effect of methotrexate on levels of peripheral blood mononuclear cells
Started 12 December 2017 | PGIMER (Intramural) | 4,94,000 | This study plans to lookd at CD161+ T cells and their cytokine profilles in serum and synovial fluid of RA patients. | |
Area Of
Specialization |
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Rheumatoid Arthritis, Other arthritides, Spondyloarthritis Systemic Lupus erythematosus
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| Awards & Honours |
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Indian Rheumatology Association Zydus Oration (Young rheumatologist) 2017 at Lucknow, Best paper award Indian Rheumatology Association 2008 Pune for Apoptosis in SLE, Indian Journal of Rheumatology best paper award 2018 for 'RANKL and OPG levels in rheumatoid arthritis'.
Japanese college of rheumatology international fellowship 2013 for 'Starting dose of methotrexate in rheumatoid arthritis', Japansese college of rheumatology international school 2014, DHR International fellowship to Liverpool UK 2016-17 to work in Neutrophils in RA, ARA-APLAR Fellowship to Adelaide in 2015 for folic acid dose with methotrexate, Asia Pacific League Against Rheumatism Best abstract and travel grant 2012, Jordan for Serum Levels of MPIF-1 (CCL23) ain Rheumatoid Arthritis
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Member Of Professional
Bodies |
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Indian Rheumatology Association, Association of Physicians of India, Indian Immunology Society, Indian society for primary immunodeficiency
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Publications(In Vancouver Style) |
https://scholar.google.co.in/citations?user=m1dcXJcAAAAJ&hl=en Pubmed indexed 70, total 140
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