Dr. Ritu Aggarwal
Designation : Professor
Department : IMMUNOPATHOLOGY
aggarwal.ritu@pgimer.edu.in

 
 
 :: Contact Details
  Phone No.    :   7087008189
  Ext No.        :   5189
 :: Educational Qualification
  Graduation :   --
  Post Graduation :   MD (Pathology)
  Other Qualification.(1)      :   DNB (Pathology)
     
 :: Area of Interest
       Area Of Interest       :

Human Papilloma virus (HPV), Cervical cancer, Immunogenetics, retinoblastoma

     
 :: Research & Projects
      Extramural Projects       :

Principal Investigator

  1. CNS infections in Indian children: Predisposing factors and biochemical and neuronal markers for diagnosis and prognosis (improving diagnosis and prevention). 2013-16. Astrid Lindgren Children’s Hospital, Karolinska Institute, Sweden (Co-PI).
  2. Epigenetic alterations in HPV infected and HPV non-infected Retinoblastoma. 2015-18. DBT.
  3. Duplex Loop mediated isothermal amplification assay for detection of HPV: A low cost option for cervical cancer screening in developing countries. 2012-13. ICMR.
  4. To study the prevalence of Herpes simplex virus in oral mucosal lesions in children with leukemia undergoing chemotherapy. 2009-11. ICMR.
  5. FIST-DST fund for improvement of science and technology infrastructure in higher educational institutions. 2009-13. DST.

Co-investigator

  1. Role of molecular neurobiochemical markers in diagnosis and prediction of outcome of meningitis in children. 2011-14. ICMR.
  2. Evaluation of burden of SCN1A mutation in children with suspected Dravet syndrome. 2015-18. ICMR.
  3. Killer immunoglobulin like receptor gene polymorphism in childhood acute lymphoblastic leukemia. 2013-15. ICMR.
  4. Assessment of activity of L-asparaginase in childhood acute lymphoblastic leukemia by estimation of ammonia levels and anti L-asparaginase antibodies. DST, Chandigarh.
  5. Analysis of HLA allele polymorphism in patients with primary biliary cirrhosis. 2007-09. ICMR.
      Departmental / P.G.I.
      Projects      		 :

Principal Investigator

  1. Toll-like receptor transcriptome in HPV-positive cervical carcinoma. 2013-15.
  2. To investigate HLA-B*1502 as susceptibility marker of drug induced Steven Johnson Syndrome and Toxic Epidermal necrolysis. 2012-13.
  3. Detection of oncogenic human papillomavirus and its variants in sporadic retinoblastoma. 2011-12.
  4. Prevalence of genital high-risk HPV in women infected with human immunodeficiency virus-1. 2010-11.
  5. Genetic susceptibility in Henoch- Schonlein purpura: a pilot study. 2009-10.

Co-investigator

  1. To identify tissue biomarkers as predictors of progression from HPV positive cervical tissue to cervical cancer. 2013-15.
  2. The predictive and diagnostic value of cytokines- IL-5, IL-6, IL-8 and C-reactive protein in childhood oncology patients with febrile neutropenia. PGIMER research grant, 2007-09.
      Research In
      Progress      		 :
      Area Of
      Specialization      		 :

Immunopathology

      Awards & Honours       :

  1. Fellowship awarded by ICMR, Dept. of Health Research, New Delhi: Two months fellowship at the Institute of Bioinformatics, Bangalore (August-October 2012) to learn various aspects of proteomics and bioinformatics.

  2. Awarded certificate of appreciation for presenting a high quality published research on the annual research day of the PGIMER, Chandigarh, 25 October 2014.

  3. First prize. Poster - Oncology. Aggarwal R, Naru J, Singh U, Mangat NK,  Kakkar N, Marwaha RK, Bansal D.Human Papilloma virus-16 is isolated in 1/4th eyes with non-familial retinoblastoma: A prospective case-control study in north Indian children. 18thAnnual conference of Pediatric Haemato-Oncology Chapter of Indian Academy of Pediatrics, Chennai. 11-12 Oct 2014.

  4. 2nd prize, poster. Agarwal R, Bansal D, Naru J, Salaria M, Minz RW, Trehan A, Marwaha RK. Detection of oral herpes simplex virus 1 and 2 in children on chemotherapy:a comparison of serology, conventional PCR and quantitative real-time PCR. 17thAnnual Conference of the Pediatric Hematology/Oncology Chapter of Indian Academy of Pediatrics, N Delhi, 19-20 Oct 2013. Poster No 49.

  5. Bestposter: Suri V, Awasthi S, Aggarwal R, Jha V, Minz M. Human Papilloma Virus genotyping in cervix of female renal transplant recipients. 18thAnnual Conference of Association of Gynaecological Oncologists of India. Nov 6-8, 2009. Oswal Cancer Treatment and Research Foundation, Ludhiana, Punjab.

  6. Bestposter: Minz RW, Kaur N, Anand S, Aggarwal R, Saikia B, Das A, Chawla YK. Complete spectrum of AMA-M2 positive liver disease in North India at the Conference of Indian National Association for Study of the liver (INASL), Chandigarh, 25-27 March 2011.

  7. Outstanding abstract award. Rana A, Minz RW, Aggarwal R, Anand S, Singh S. Relative gene expression analysis of cytokines IFN-y and TNF-ά of cytokines and its association with autoantibody profile and disease activity in pediatric SLE. 9th International Lupus congress, Vancouver, Canada. 24-27 June 2010.

  8. FIMS award: Rana A, Minz RW, Aggarwal R, Anand S, Singh S. Epstein Barr virus immune response, viral load and association with disease activity in Pediatric Systemic Lupus Erythematosus. 5th Federation of Immunological Societies of Asia-Oceania congress, New Delhi, 14-17 March 2011.

  9. Awarded he Membership of the National Academy of Medical Sciences (MNAMS) in the year2009.
      Member Of Professional
      Bodies      		 :
Life member
  1. Indian Academy of Pathologists and Microbiologists
  2. Indian Immunology Society
  3. Indian Association of Cancer Research
  4. Indian Society for Primary Immune Deficiency Diseases
Annual member
  1. American Association of Histocompatibility and Immunogenetics
  2. International Society of Pediatric Oncology
     
 :: Publications(In Vancouver Style)
https://scholar.google.com/citations?hl=en&view_op=list_works&gmla=AJsN-F7RMT5af1Cl_VrtNH6XLVz-ze2Gn_bnq42HTmLKVzBXNB59ZBWvrKSKvswiUfJK2HXFHbNuB0kAfqFxMCSz2rI--VuK_Cj8C3R7f6Pl8VnK6GZtD3Ri9fCBdYATB3_cUrcREc1m&user=L2Hehi4AAAAJ

  1. Aggarwal R, Misra S, Guleria C, Suri V, Mangat N, Sharma M, Nijhawan R, Minz R. Characterization of Toll-like receptor transcriptome in squamous cell carcinoma of cervix: A case-control study. Gynecol Oncol. 2015 May 27. [Epub ahead of print]

  2. Aggarwal R, Sharma M, Modi M, Garg VK, Salaria M. HLA –B*1502 is associated with carbamazepine induced Stevens-Johnson syndrome in North Indian population. Hum Immunol 2014;75:1120-2.

  3. Aggarwal R, Suri V, Awasthi S, Naru J, Nijhawan R, Minz M, Jha V. Prevalence and genotypes of HPV in female renal transplant recipients in North India. Int J Gynecol Pathol 2014; 33: 537-42.

  4. Aggarwal R, Bansal D, Naru J, Salaria M, Rana A, Minz RW, Trehan A, Marwaha RK. HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy. Support Care Cancer 2014; 22:1773-9.

  5. Aggarwal R, Bansal D, Bansal F, Nanda N, Ray P, Trehan A, Marwaha RK. IL-5, IL-6, IL-8 and TNF-α levels obtained within 24 hours of admission does not identify high risk children with febrile neutropenia. Indian J Med Microbiol 2013; 31:226-9.

  6. Aggarwal R, Sachdeva RK, Naru J, Suri V, Sharma A, Nijhawan R. HPV genotyping in North Indian women infected with HIV. Int J Gynecol Pathol 2012; 31: 475-81.

  7. Kaur N, Minz RW, Anand S, Saikia B, Aggarwal R, Das A, Thapa BR, Chawla YK. HLA-DRB1 allele discriminate the manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian population. J Clin Exp Hepatol 2014; 4:14-18

  8. Minz RW, Khairwa A, Aggarwal R, Kaur H, Singh S, Sharma A, Varma S, Mathuria SN, Pasricha N. Cost analysis and benefits of opt-out HIV testing at a tertiary care centre in northern India. Int J STD AIDS. 2014 ;25:341-7.

  9. Mittal N, Bansal R, Nada R, Minz R, Minz M, Joshi K. Light chain deposition disease in a post renal transplant patient. Indian J Nephrol. 2012; 22:221-3

  10. Rana A, Minz RW, Aggarwal R, Anand S, Singh S. Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus 2012; 21: 1105-12.

  11. Rana A, Minz RW, Aggarwal R, Sharma S, Pasricha N, Anand S, Singh S. A comparative proteomic study of sera in paediatric systemic lupus erythematosus patients and in healthy controls using MALDI-TOF-TOF and LC MS-A pilot study. Pediatr Rheumatol Online J 2012; 10:24.

  12. Minz RW, Kaur N, Anand S, Aggarwal R, Saikia B, Das A, Chawla YK. Complete spectrum of AMA-M2 positive liver disease in North India. Hepato lnt 2012;6:790-95.

  13. Kansal S, Negi AK, Kaur R, Sarotra P, Sharma G, Aggarwal R, Agnihotri N. Evaluation of the role of oxidative stress in chemo preventive action of fish oil and celecoxib in the initiation phase of 7,12-dimethyl benz(α) anthracene-induced mammary carcinogenesis. Tumour Biol 2011; 32:167-77.

  14. Minz RW, Singh S, Varma S, Mathuria SN, Aggrawal R, Sehgal S. Relevance of opt-out screening for HIV in emergency and pre-surgery patients in a tertiary care center in Northern India: a pilot study. Indian J Pathol Microbiol 2010;53:287-9

  15. SarotraP , Sharma G, Kansal S, Negi AK, Aggarwal R, Sandhir R, Agnihotri N. Chemo preventive effect of different ratios of fish oil and corn oil in experimental colon carcinogenesis. Lipids 2010; 45:785-98.

  16. Sehgal S, Mujtaba S, Gupta D, Aggarwal R, Marwaha RK. High incidence of Epstein Barr virus infection in childhood acute lymphocytic leukemia: a preliminary study. Indian J Pathol Microbiol 2010; 53:63-7

  18. Dutta N, Sarotra P, Gupta S, Aggarwal R, Agnihotri N. Mechanism of action of celecoxib on normal and acid-challenged gastric mucosa. Exp Toxicol Pathol  2009; 61:353-61.

  19. Aggarwal R, Stamm L, Zhao W, Fernandez-Vina M, Senitzer D, Berka N. A novel HLA-B allele, B*4093, sharing sequences with B*4006 and B*0702 in an Asian Indian donor. Tissue Antigens 2008; 72:492-4.

  20. GuptaS, Aggarwal R, Gupta S, Arora SK. Human papilloma virus and skin tags: is there any association? Indian J Dermatol Venereol Leprol 2008; 74:222-5.

  21. Gupta S, Sarotra P, Aggarwal R, Dutta N, Agnihotri N. Gupta S, Sarotra P, Aggarwal R, Dutta N, Agnihotri N. Role of oxidative stress in celecoxib-induced renal damage in wistar rats. Dig Dis Sci 2007; 52:3092-8.

  22. Aggarwal R, Gupta S, Nijhawan R, Suri V, Kaur A, Bhasin V, Arora SK. Prevalence of high - risk Human papilloma virus infection in women with benign cervical cytology: a hospital based study from North India. Ind J Cancer 2006; 43:110-16.

  23. Payal R, Gupta S, Aggarwal R, Handa S, Radotra BD, Arora SK. Detection of high-risk human papillomavirus type 16/18 in cutaneous wart in immunocompetent patients using polymerase chain reaction. Dermatol online Journal 2006; 12.

  24. Aggarwal R, Dhawan SB, Mohan H, Ahluwalia M. Endometrial biopsy in infertility. Asian Journal of Obs and Gynae Practice 2004; 8:30-2.

  25. Tahlan A, Aggarwal R, Bawa AS. Testicular microlithiasis in a child with cryptorchidism. Gazzetta Medica Italiana Archivio per le Scienze Mediche 2005 ;164: 325.

  26. Dhawan SB, Aggarwal R, Mohan H, Bawa AS. Adrenocortical carcinoma: diagnosis by fine needle aspiration cytology. Indian J Pathol Microbiol 2004; 47:44-5.

  27. Mohan H, Aggarwal R, Tahlan A, Bawa AS, Ahluwalia M. Giant adrenal pseudocyst mimicking a malignant lesion. Can J Surg 2003; 46:474.

  28. Punia RS, Aggarwal R, Amanjit, Mohan H. Xanthogranulomatous oophoritis and salpingitis: late sequelae of inadequately treated staphylococcal PID. Indian J Pathol Microbiol 2003; 46:80-1.

  29. Dhawan SB, Aggarwal R, Mohan H, Kumar S. Cytodiagnosis of enchondroma. Cytopathology 2003; 14:157-9.

  30. Mohan H, Aggarwal R, Nada R, Punia RP, Ahluwalia M. Trichinosis of psoas muscle. J Assoc Physicians India. 2002; 50:729-30.

  31. Punia RPS, Aggarwal R, Mohan H, Ahluwalia M. Aspiration cytology of Rheumatoid nodulosis : diagnostic method of choice. Acta Cytol 2002; 46:1175-6

  32. Mohan H, Aggarwal R, Abrol R. Laryngeal paraganglioma. J Otolaryngol 2001; 30:357-8

  33. Jaswal TS, Singh S, Aggarwal R, Singh M, Khatri HL, Arora B. Pseudo myxomaperitoni of hernial sac – a case report. Indian J Pathol Microbiol 2001: 44:151-152.