Principal Investigator

1. To investigate the mitochondrial network dynamics during differentiation of humanmesenchymal stem cells to cardiomyocytic and adipocytic lineage in vitro (ICMR)-(No.80/12/2011-BMS)2012-15
2. Potential role of Hedgehog pathway mediators during Epithelial to mesenchymal transition and cancer stem cell phenotype in cervical cancer.- recommended for sanction by DBT .
3. Evaluation of the antioxidant potential of Spirulina & vitamin C incisplatin induced nephrotoxicity (UGC-F No 33-469/2007)
   
4. Effectsof C-phycocyanin on antitumoural activities and molecular mechanisms ofchemotherapeutic drugs in vitro[CSIR-27(0197)/09/EMRII].

1.      Analysis of mineral composition of primary renal stones from children in North India by FTIR (PGI-pvt.grant)(No.71/2-Edu/09/962).2009-2011

2.      A pilot study to identify cancer stem cells in invasive cervical cancer cell line (PGI-pvt.grant). (No.71/2-Edu/09/872) 2010-2011

3.      A preliminary study to correlate antioxidant levels with a novel marker in renal cell carcinoma (PGI pvt. grant) (No.71/4-Edu/11/688).2011-2013

4.      The role of autophagy modulation on Th1/Th2 cytokines expression in urothelial carcinoma (PGI pvt.grant). 2012-2014 (No.71/5-Edu/12/866)

·        1. Identification of the Mediators of Hedgehog Pathway Involved in Epithelial-Mesenchymal Transition in Cervical Cancer Cell Lines.

• Dr. Bhattacharyya's lab is engaged in studies on fundamental aspects of  cancer cell physiology including morphological changes and invasiveness due to epithelial to mesenchymal transition and cancer stem cell phenotype. Her laboratory is presently focused on further studies in identifying the cancer stem cell (CSCs) and targeting autophagy and other the pathways involved in CSC survival.

• ·     Another area of research being pursued in the laboratory is the application of human dental stem cell in regenerative medicine and tissue engineering. Both in vivo and in vitro studies are being carried out in her laboratory.

• Spectroscopic analysis using FTIR is also being carried out as a part of patient care.
  

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1.   Young Scientist award (New Biology) by Indian Science Congress,

2.   Certificate of distinction for oral presentation in 2^nd Medical Olympiad, Greece

3.      Awarded travel fellowship by the Hellenic Society of Nuclear Medicine,Thessaloniki,Greece,

4.      Fellow of International society of Biotechnology (FISBT)

5.   Awarded  A grade in UGC-sponsored Orientation Programme in Academic Staff College (Panjab University)

6.   Awarded Research Fellowship by the Council of Scientific and Industrial Research (CSIR), Govt of India.

7.   Qualified in Graduate Aptitude Test in Engineering (GATE).

8.   Merit Scholarship by Chandigarh Admin, Govt of India.

9.   Certificate of Merit in M.Sc (Hons) in Biophysics, Panjab University.

10.        Certificate of Merit for BSc (Hons) 3^rd year Biophysics, Panjab University, Chandigarh.

11.        National Scholarship in All India Senior School Certificate Examination by the Central Board of Secondary Education, Govt of India.

Member National Academy of Medical Sciences

Member,Editorial Board, Stem Cell Studies

Member, Editorialboard, Research Journal of Biotechnology

Fellow-International Society of Biotechnology

Life Member-Indian Science Congress Association

Life Member-Indian Biophysical Society

1.    

1. Klionsky DJ...…BhattacharyyaS et al. Guidelines for the use and interpretation of assays for monitoringautophagy (3rd edition). Autophagy. 2016;12(1):1-222.
2.  Bhattacharyya S,Sharma V. C-Phycocyanin modulates the cytotoxicity of platinum based anticancerdrugs in lung cancer cell lines. Int. Jour. Sc. Res.2016,  5 (2)
3. Mahalingam H, Lal A, Mandal AK, Singh SK, Bhattacharyya S, Khandelwal N. Evaluation of low-dose dual energycomputed tomography for in vivo assessment of renal/ureteric calculuscomposition. Korean J Urol.2015;56(8):587-93. doi: 10.4111/kju.2015.56.8.587. Epub 2015 Aug 10.
4.  Kumar A, Bhattacharyya S *, Rattan V. Effect of uncontrolled freezing onbiological characteristics of human dental pulp stem cells. Cell Tissue Bank. 2015 , 16 (4):513-522
5. Ojha R, Bhattacharrya S*, Singh SK. Autophagyin cancer stem cells: potential link between chemoresistance, recurrence andmetastasis. BioResearch Open Access.2015, 4(1): 97-108..(*corresponding author)
6.  BhattacharyyaS Fourier Transform Infrared Spectroscopy: Applications in Medicine. J PhysChem Biophys . 2015, 5:e128. doi:10.4172/2161- 0398.1000e128
7.  Ojha R, Jha V, Singh SK, Bhattacharrya S.* Autophagy inhibitionsuppresses the tumorigenic potential of cancer stem cell enriched sidepopulation in bladder cancer. Biochim Biophys Acta. 2014;1842(11): 2073-86. (*correspondingauthor)
8.  Ojha R,Singh SK, Bhattacharyya S, DhandaRS, Rakha A, Mandal AK, Jha V. Inhibition of grade dependent autophagy inurothelial carcinoma increases cell death under nutritional limiting conditionand potentiates the cytotoxicity of chemotherapeutic agent. J Urol. 2014;191(6):1889-98.
9.  Bhattacharyya S*,Sharma G, Mandal AK,Singh SK. Analysis of thechemical composition of urinary calculi using Fourier transform infraredspectroscopy - A preliminary study.  J Postgrad Med Edu Res2014;48(3):128-31. (*correspondingauthor)
10.  Ojha R., Singh SK, Jha V, Bhattacharyya S, and Mandal AK. Inhibition of autophagy: A novelwindow for overcoming therapeutic resistance in Carcinoma of Urinary bladder. Urol Suppl. 2014; 84 (4) S 1
11. Bhattacharyya S, Kumar A, Sharma V, Rattan V, Jha V. Exploring dental tissue as a potential source of human stem cells inregenerative medicine. Hellenic Journalof Nuclear Medicine 2014;17 (suppl): 86
12.  Ojha R., Singh SK,  BhattacharyyaS, Mandal AK, and Jha V. Inhibitorsof autophagy potentiate the cytotoxic effect of chemotherapeutic agents inurothelial carcinoma of urinary bladder. J Urol. 2014;191, 4S,e370
13.  Ojha R., Singh SK, BhattacharyyaS, Mandal AK, and Jha V. Calcium mediated autophagy induction preserve cellsurvival during endoplasmic reticulum stress in bladder cancer. J Urol. 2014;Supplement, MP39-01
14.  OjhaRU, Singh SK, Bhattacharyya S, SinghR, Rakha A, Joshi K, Mandal AK, Jha V. Grade associated autophagy regulationvia ampk and mtor contributes to urothelial cancer cell survival. J  Urol. 2013; 189, no. 4: e463.
15.  Bhattacharyya S*, Kumar A, Khanduja KL. The voyage of stem cell towards terminal differentiation - A briefoverview. Acta Biochim Biophys Sin (Shanghai).2012;44(6):463-75. (*corresponding author)
16.  Bhattacharyya S*. Advances and Applications in Stem CellBiology. J Postgrad Med Edu Res. 201246 (2),75-80. (*corresponding author)
17. Ganesamoni R, Bhattacharyya S, Kumar S, Chauhan A, Mete UK,Agarwal MM, Mavuduru R, Kaushik G, Mandal AK, Singh SK. Status ofoxidative stress in patients with renal cell carcinoma. J Urol.2012;187(4):1172-6.
18.  BhattacharyyaS* and Mehta P. The Hepatoprotective Potential of Spirulina and Vitamin CSupplemention in Cisplatin Toxicity. Food Funct. 2012;3(2):164-9. (*corresponding author)
19.  Kaur B, Yadav SK, Sharma SK,Bhattacharyya S, Khanduja KL, PathakCM. Cigarette smoke condensate induces the expression of sPLA2 isoforms inhuman macrophage like THP-1 cells. J ThocOncol. 2012; 7;S173-174.
20.  OjhaRU, Singh SK, Bhattacharyya S, SinghR, Rakha A, Joshi K, Mandal AK, Jha V. Role ofoxidative stress and autophagy in progression of urothelial carcinoma ofbladder.  EP 26, Urol. Suppl.(3A),September 2010.
21. Bhattacharyya  S and Khanduja KL. Cancer Stem Cells - New hope in the horizon. Acta Biochimica Biophysica Sinica, 2010,42(4):237-242. (*corresponding author)
22.  Ghadi FE, Ghara AR, Bhattacharyya S, Dhawan DK. Selenium as a chemopreventive agent inexperimentally induced colon carcinogenesis. World JGastrointest Oncol. 2009; 1(1):74-81.
23.  Bhattacharyya S and Mehta P. Use of99mTc ethylene dicystein in evaluating the protective efficacy of spirulina incisplatin induced nephrotoxicity. J Nucl.Med. (Suppl.) 2009, 276.
24.  Bhattacharya  S and Khanduja KL. Bioinformatics in Biology.Bull PGI, 2008; 28, 115-118. (*corresponding author)
25.  Goyal A, Bhattacharyya S, Majumdar S, Narang A, Ghosh S. Cellular Response Induced by a Galactose Specific Adhesin ofEnteroaggregative Escherichia coli inINT-407 Cells. FEMS Immunol Med Microbiol.2009; 55(3): 378-387.
26. Bhattacharyya S, Shant J, Ganguly NK, Majumdar S, Ghosh S. A potential epidemicfactor from the bacteria, Vibrio cholerae WO7. Curr Microbiol. 2008; 56(1):98-103.
27.  Majumdar S, Bhattacharyya S, Ghosh S, Majumdar S,Ganguly NK. The role of heat shock protein from V.cholerae 0139 in gut immune response.  MolCell Biochem. 2007;297: 9-19.
28.  Bhattacharyya S, Ghosh S, Majumdar S.W07-toxin induced apoptosis in a human intestinal cell line. Ind J Gastroenterol; 2006; 25 (suppl 2):A128.
29. Shant J, Ghosh S, BhattacharyyaS, Ganguly NK, \Majumdar S. Mode of action of a potentially importantexcretory-secretory product from Giardia lamblia in mice enterocytes. Parasitology. 2005; 131:1-13.
30. Shant J, Ghosh S, BhattacharyyaS, Ganguly NK, Majumdar S. The alteration in signal transduction parametersinduced by excretory-secretory product from G lamblia. Parasitology. 2004; 129: 421-430.
31. Bhattacharyya S, Ghosh S, Shant J, Ganguly NK, Majumdar S. Role of the W07-toxin onVibrio cholera - induced diarrhea. Biochimicaet Biophysica Acta. 2004; 1670(1), 69-80.
32. 32. Bhattacharyya S, Ghosh S, Shant J, Ganguly NK, Majumdar S. Effect of W07-toxin ongut physiological response in mice. MicrobialPathogenesis. 2004; 37: 1-9.
33. Shant J, Bhattacharyya S, Ghosh S, Ganguly NK, Majumdar S. Apotentially important excretory-secretory product of Giardia lamblia. Experimental Parasitol. 2002; 102:178-186.
34.   Bhattacharyya S, Ghosh S, Ganguly NK,Majumdar S. Study of intestinal electrolyte transport with a non-CT toxin. Ind J Gastroenterol; 2002; 21 (suppl 1):A14.
35.  Bhattacharyya S, Ghosh S, Majumdar S,Ganguly NK. A novel non-CT toxin from the epidemic strain of V cholerae W07.Ind J Gastroenterol; 1999; 18 (suppl2): A53.
36.  Bhattacharyya  S and Dhawan DK. Zn ⁶⁵ in the assessment of lead toxicityin rat liver. Ind J Nucl Med (S);1997: 155.