Dr. Gaurav Sharma
Designation : Associate Professor
Department : TRANSLATIONAL AND REGENERATIVE MEDICINE
sharma.gaurav@pgimer.edu.in

 
 
 :: Educational Qualification
  Graduation :   B.Sc (Hons) Microbiology from Delhi University INDIA in year 2002
  Post Graduation :   M.Sc (Medical Biotechnology) from PGIMER Chandigarh INDIA in year 2005
  Other Qualification.(1)      :   PhD (Immunology) from AIIMS New Delhi INDIA in year 2011
  Other Qualification.(2)      :   Collaborative Research from NIH Frederick USA in year 2014
  Other Qualification.(3)      :   Collaborative Research from Tokai University Isehara JAPAN in year 2018
     
 :: Area of Interest
       Area Of Interest       :
  1. To explore Human Leukocyte Antigens(HLA) as mini genome model in health and disease. With particular emphasis towards generating high resolution database for establishing HLA registry at PGIMER for a) Hematopoietic Stem Cell Transplantation (HSCT) for patients with various malignant and non-malignant hematopoietic conditions) and  b) towards histocompatible stem cell banking
  2. Influence of HLA-KIR axis on immune reconstitution, disease relapse, GVHD and GVL after haploidentical HSCT for various malignant and non malignant haematopoietic diseases
  3. To establish Multi-Lineage Chimerism approach for clinical practice in Post HSCT monitoring
     
 :: Research & Projects
      Extramural Projects       :
      Departmental / P.G.I.
      Projects      		 :
Elucidating the cellular and molecular mechanisms behind the immunomodulatory effects of human umbilicalcord derived-mesenchymal stem cell treatment in animal model of Rheumatoid arthritis
      Area Of
      Specialization      		 :
Histocompatibility and Immunogenetics
      Future Plans       :
Please refer Area of Interest as above
      Awards & Honours       :

S.No

Name of Award (International)

Awarding Agency

Year

1

FIMSA (Federation of Immunological Societies of Asia Oceania) Award

FIMSA

2008

2

IUIS (International Union of Immunological Societies) Travel award

IUIS

2010

3-4

Global Health Awards by Bill and Melinda Gate Foundation (2010 and 2012)

Bill and Melinda Gate Foundation

2010 & 2012

5

Young Immunologist Award by Chinese Society for Immunology (CSI)

CSI

2015

6

Travel Award by Chinese Society for Immunology (CSI)

CSI

2019

S.No

Name of Award (National)

Awarding Agency

Year

1

ICMR-JRF-SRF

ICMR

2005-2010

2

Qualified CSIR-NET (Dec, 2004)

CSIR

2004

3

CSIR-travel grant

CSIR

2010

4

Best Oral Presentation Award, ISHI 2016 conference held at PGIMER, Chandigarh

Indian Society of Histocompatibility and Immunogenetics (ISHI)

2016

5

Best Poster Award in the “3rd ISHI conference” (New Delhi; 2013)

ISHI

2013

6

Best Participant Award in the FIMSA/IUIS/IIS Advanced Course on Basic and Translational Immunology, held in New Delhi

FIMSA/IUIS/IIS

2012

7-8

TWAS (The World Academy of Sciences) Travel grants (2015 and 2017)

TWAS

2015 & 2017
      Member Of Professional
      Bodies      		 :

1) Life member of Indian Immunology Society(IIS) (Elected Executive Council member since Nov, 2018)

2)  Life member of Indian Society forHistocompatibility and Immunogenetics (ISHI)

3) General Assembly member in InternationalUnion of Immunological Societies (2010-2013)

4) Member of AIIMS Scientists Association (ASA)
     
 :: Publications(In Vancouver Style)


1.    Saxena A, Sharma G, Tyagi S, Mourya M, Coshic P, Tiwari PK, Mehra NK, Kanga U. HLA-A*02 repertoires in three defined population groups from North and Central India: Punjabi Khatries, Kashmiri Brahmins and Sahariya Tribe. HLA. 2019 Jan;93(1):16-23. (Cited by 3) (Joint 1st author) (Impact Factor: 4.5)

2.    Ramsuran V, Hernández-Sanchez PG, O'hUigin C, Sharma G, Spence N, Augusto DG, Gao X, García-Sepúlveda CA, Kaur G, Mehra NK, Carrington M. Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes. Journal of Immunology. 2017 Mar 15;198(6):2320-2329. (Cited by28) (Impact Factor: 5.1)

3.    Naruse TK, Sakurai D, Ohtani H, Sharma G, Sharma SK, Vajpayee M, Mehra NK, Kaur G, Kimura A. APOBEC3H polymorphisms andsusceptibility to HIV-1 infection in an Indian population. Journal of Human Genetics. 2016 Mar;61(3):263-5. (Cited by 20) (Impact Factor: 2.9)

4.    Kaur G, Sharma G, Kumar N, Kaul MH, Bansal RA,Vajpayee M, Wig N, Sharma SK, Mehra NK. Genomic architecture of HIV-1infection: current status & challenges. Indian Journal of Medical Research. 2013 Nov;138(5):663-81. (Cited by 8) (Impact Factor: 1.5)

5.     Sharma G, Ohtani H, Kaur G, Naruse TK, Sharma SK, Vajpayee M, Kimura A, Mehra N. Status of TIM-1 exon 4 haplotypes and CD4+T cell counts in HIV-1 seroprevalent NorthIndians. Human Immunology. 2013Feb;74(2):163-5. (Cited by 7) (Impact Factor: 2.9)

6.    Kumar N, Sharma G, Kaur G, Tandon N, Bhatnagar S, Mehra N. Major histocompatibility complex class I chain related gene-A microsatellite polymorphism shows secondary association with type 1 diabetes and celiac disease in North Indians. HLA. 2012 Oct;80(4):356-62. (Cited by 22) (Impact Factor: 4.5)

7.     Kaur G, Kumar N, Nandakumar R, Rapthap CC, Sharma G, Neolia S, Kumra H, Mahalwar P, Garg A, Kumar S et al. Utility of saliva and hair follicles in donor selection for hematopoietic stem cell transplantation and chimerism monitoring. Chimerism. 2012 Jan-Mar;3(1):9-17.(Cited by 9)

8.    Sharma G, Kaur G, Mehra N. Genetic correlates influencing immunopathogenesis of HIV infection. Indian Journal of Medical Research. 2011 Dec;134(6):749-68. (Cited by 22) (Impact Factor: 1.5)

9.     Mahajan N, Dhawan V, Sharma G, Jain S, Kaul D. Induction of inflammatory gene expression by THP-1 macrophages cultured in normocholesterolaemic hypertensive sera and modulatory effects of green tea polyphenols. Journal of Human Hypertension. 2008 Feb;22(2):141-3. (Cited by 20) (Impact Factor: 2.4)

10.  Singh P, Kaur G, Sharma G, Mehra NK. Immunogenetic basis of HIV-1 infection, transmission and disease progression. Vaccine. 2008 Jun 6;26(24):2966-80. (Cited by 63) (Impact Factor: 3.14)

11.  Kaur G, Singh P, Kumar N, Rapthap CC, Sharma G, Vajpayee M, Wig N, Sharma SK, Mehra NK. Distribution of CCR2 polymorphism in HIV-1-infected and healthy subjects inNorth India. International Journal ofImmunogenetics. 2007 Jun;34(3):153-6. (Cited by 13) (Impact Factor: 0.41)

 

Acknowledged in publications for myrole in the study:

 

1.     Nakajima T, Kaur G, Mehra N, Kimura A. HIV-1/AIDS susceptibility and copy numbervariation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptorCCR5. Cytogenetics Genome Research.2008;123(1-4):156-60. (Cited by 39) (Impact Factor: 1.6)

2.     Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya JI, Ohtani H, Mehra N, Shioda T, Kimura A. Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on theanti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS. 2009 Oct 23;23(16):2091-100.(Cited by 31) (Impact Factor: 4.5)

 

Abstracts Published in Scientific Journals (last 3 years)

 

1.    Sharma G*. Immunogenetic correlates of HIV-1in North Indian population. European Journal of Immunology. ISSN 0014-2980 Vol. 49. Supplement S3-2019;290 (Impact Factor 5.2)

2.     Sharma A, Sharma G, Neolia S, Mitra DK, Kanga U. STR based chimerism monitoring post hematopoietic stem celltransplantation. European Journal of Immunology. ISSN 0014-2980 Vol. 49. Supplement S3-2019;290 (Impact Factor 5.2)

3.    Sharma G*, Kaur G, Mehra NK, Sharma SK. Influence of cytokine gene polymorphisms on HIV infection in North Indians. HLA. 2018;91(5): 467 (Impact Factor 4.5)

4.    SharmaG*, Kaur G, Mehra NK. Polymorphisms in pro and anti-inflammatory cytokine genes and HIV infection in North Indians. Human Immunology. 2018;79: 109 (Impact Factor 2.9)

 


Books/Reports/Chapters/General articles etc.

 

S.No

Title

Author’s Name

Publisher

Year

 

1

Emergence of COVID-19 Pandemic.

Mehra NK, Sharma G*

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 7-26

2021

2

Immunopathogenesis in COVID-19.

Sharma G*, Mehra NK

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 27-36

2021

3

Immune Correlates of COVID-19 Vulnerability.

Mehra NK, Sharma G*

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 37-56

2021

4

Immunological Considerations for COVID-19 Vaccines.

Mehra NK, Sharma G*

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 57-68

2021

5

Genes May Decide the Coronavirus Disease Course.

Sharma G*, Mehra NK

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 69-84

2021

6

COVID-19 Infection and Vaccines: Indian Response.

Arora NK, Sharma G*

In: Mehra NK, Mehendale SM, Sharma G, Arora NK, Bhan A, editors. Host Immunity and Vaccines for COVID-19-A White Paper. Indian National Science Academy New Delhi: 2021 p 103-114

2021

7

The human leukocyte antigen system in human disease and

transplantation medicine (Book: Clinical Molecular Medicine)

 Sharma G, Baranwal A,  Mehra NK

Elsevier

2020

8

Genetic parameters in tuberculosis

susceptibility (Tuberculosis)

 Mehra NK, Sharma G, Bhat DK

Jaypee Brothers Medical Publishers

2020

9

From genome science to genetic medicine: Opportunities and challenges.

 Mehra NK, Sharma G, Kaur G, Kumar N

Proceedings of 19th annual symposium of Ranbaxy science foundation.

2014

10

Genomic Architecture of HIV infection: Current status and challenges.

 Kaur G, Sharma G, Kumar N, Mehra NK et al. (2014).

Proceedings of 19th annual symposium of Ranbaxy science foundation.

2014