Pathogenesis and exploration of immunotherapeutic approaches in type-1 diabetes (T1D)

·       Manipulation of preproinsulin-specific regulatory T cells for therapeutic approaches in T1D

Combining the approaches of identification of epitope-specific regulatory T cells (Tregs) using MHC multimers and Treg specific markers can facilitate the scope of antigen-specific immunotherapy in humans. Animal studies have indeed shown that islet antigen-specific Tregs can indeed reverse T1D by targeting T cells that infiltrate pancreas. Our lab is involved in generating and manipulating preproinsulin-specific Tregs from natural and induced Tregs and assessing their specificity, stability and suppressive ability to inhibit beta cell-specific effector T cells to prevent T1D in vitro and in vivo.

·       Innate immune mechanisms involved in initiation and pathogenesis of T1D

The initial pathogenic mechanisms involved in the cross-talk of innate immune cells and beta cells during initiation of T1D are far from clear. Our current study is focused to elucidate the role of plasmacytoid dendritic cells (pDCs) and monocytes in initiation of T1D via self-nucleic acid complexes. The study is investigating the ability of pDCs and monocytes to capture DNA/RNA complexes released during beta-cell death, and whether the uptake of self-nucleic acid complexes influences presentation of autoantigens to activate T cells and finally, whether these activated pDCs and monocytes are capable of inducing beta-cell apoptosis.

·       Suppression of type-1 diabetes in NOD mice by induction of colonic regulatory T cells

Defects in colonic regulatory T cells (cTregs) have been found in subjects with T1D. Butyrate, a postbiotic, is shown to favor induction of cTregs via inhibition of histone deacetylase on the Foxp3 gene as well as through induction of tolerogenic dendritic cells and macrophages. We have reported the immunomodulatory effects of butyrate in NOD mice via induction of cTregs that can migrate to the pancreas and pancreatic lymph nodes. We now plan to further extend this study in human subjects to assess the therapeutic benefits of butyrate in suppression of T1D.

COLLABORATIONS (International/National)

1.     Prof Thomas Kay, Director, Unit Head, Immunology and Diabetes, Tom Mandel Islet Transplant Program, St Vincent’s Institute, University of Melbourne, Australia.

2.     Dr Tom Loudovaris, Manager, Islet isolation Center, Tom Mandel Islet Transplant Program, St Vincent’s Institute, University of Melbourne, Australia.

3.     Dr Eddie James, Prof Bil Kwok, Dr I-Ting Chow, Tetramer Core Laboratory, Benaroya Research Institute, Seattle, WA, USA.

4.     Prof Raman Kumar Marwaha, Consultant Endocrinologist and Scientific Advisor (International Life Sciences Institute (ILSI) President, Society of Endocrine Health Care for Elderly, Adolescents and Children (SEHEAC), New Delhi, India

5.     Prof Michael F Holick, Section of Endocrinology, Diabetes, Nutrition & Weight Management, Department of Medicine, School of Medicine, Boston University, Boston, MA, USA

6.     Prof Deshratn Asthana, Ex-Director, Laboratory for Clinical and Biological Studies (LCBS), University of Miami-Miller School of Medicine, Miami, FL, USA.

7.     Prof Pooja Jain, Dept. of Microbiology and Immunology, Institute for Molecular Medicine & Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.

8.     Dr C R Suri, Scientist and Incharge, Biosensor Development, Institute of Microbial Technology (IMTech), Chandigarh, India.

9.     Dr Neeraj Khatri, Scientist and Incharge, Experimental Animal Facility, Institute of Microbial Technology (IMTech), Chandigarh, India.

10.   Prof Rupinder Tewari, Prof Parveen Rishi, Prof Geeta Shukla, Dept of Microbiology, Panjab University, Chandigarh.

·       Suppression of type-1 diabetes in NOD mice by induction of colonic regulatory T cells

It has been observed that the development of clinical diabetes is preceded by intestinal alterations such asan aberrant intestinal microbiota, a leaky intestinal mucosal barrier and an altered intestinal immune responsiveness. Defects in colonic regulatory T cells (cTregs) have been found in subjects with type-1 diabetes. Butyrate, a postbiotic, is shown to favor induction and activation of cTregs via inhibition of histone deacetylase on the Foxp3gene as well as through induction of tolerogenic dendritic cells and macrophages. Through this study we plan to explore the immunomodulatory effects of butyrate in induction of cTregs and further assess their ability to migrate to pancreas and suppress type-1 diabetes in NOD mice.

1.     Trust For Education and Training in Flowcytometry (TETC) Best Published Paper Award 2024 (Research), 6^th February 2024, CSIR-CDIR, Lucknow, India.

2.     Distinguished Alumnus Award. Panjab University Alumni Association. 23rd December 2023, Panjab University, Chandigarh, India.

3.     Chellaram Foundation Diabetes Research Award and Gold Medal 2019, presented at 3rd International Diabetes Summit, Pune, India, 8-10 March, 2019.

4.     Best paper award for oral presentation in the 44th Annual Scientific meeting of the Research Society of Study of Diabetes in India (RSSDI) held in Hyderabad during 18-20 November 2016.

5.     Department of Health Research HRD fellowship - start up grant for "Development of immune monitoring assays and cellular immunomodulation strategies to improve the outcome of islet transplantation in subjects with autoimmune diabetes (in collaboration with St Vincent's Institute of Medical Research (SVI), Melbourne, Australia) in August 2016.

6.     DHR fellowship for research project “Islet isolation for clinical transplantation in subjects with type 1 diabetes” at St Vincent’s Institute of Medical Research, Melbourne, Australia, Jan – Mar 2016.

7.     Juvenile Diabetes Research Foundation Travel award, 13th International Congress of the Immunology of Diabetes Society, 7-11 Dec 2013, Lorne, Victoria, Australia.

8.     BD Biosciences research grant award (Competitive award) in Immunology and Multicolor Flowcytometry for the year 2011.

9.     Young Investigator Award in the 8th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS) at Boston, MA, USA, 5-9 June 2008. www.focisnet.org.

10.  Young Investigator Award In 14^th Conference on retroviruses and opportunistic infections (CROI), Los Angeles, USA, 25-28 Feb 2007. www.retroconference.org.

11.  R. Nath Gold Medal for best research in the field of biomedical sciences for the year 2004 at 27th annual convocation held in March 2006 at PGIMER, Chandigarh, India.

12.  2^nd prize for Oral Presentation in Ist National conference on HIV & Hepatitis Co-Infection, 25-26 Jan’2003, Mumbai India.

13.  Young Investigator travel award for 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, Brazil, 24-27 July 2005. www.ias-2005.org.

PROFESSIONAL ACTIVITIES/MEMBERSHIPS

1.    Immunology of Diabetes Society (Lifemember)

2.    The Cytometry Society (India) (Ex-ExecutiveCommittee Member)

3.    Review Editor in Frontiers inEndocrinology - Translational Endocrinology

4.    Member Editorial Board, World Journal ofImmunology

5.    Member Editorial Board, Journal ofImmunoendocrinology

6.    Member Editorial Board, Journal ofPediatric Endocrinology

7.    European Academy of Allergology andClinical Immunology (Affiliate junior member, 2005-2008)

8.    Indian Immunology Society (Life member)

9. Australia and New Zealand Society of Immunology (Overseas member)

10.    AIDS Society of India (Life member)

11.  University of Miami-Postdoctoral Association (Member, 2005-08)

12.  Association of Basic Medical Scientists, PGIMER, India (Executive Member, 1999-2003)

13.  Elected Departmental Representative, Panjab University Campus Students Council (1997-98).

13.  Participated in setting questionnaires for AIIMS and PGI, DM, Senior Demonstrator entrance exams.

REVIEW SERVICE

1.     Department of Biotechnology(DBT), Government of India: Task Force: Endocrine, Cardiac & Renal,Autoimmune Diseases & Reproductive Biology

2.     Science and Engineering Research Board (SERB) (under DST, GOI)

3.     Council of Scientific and Industrial Research (CSIR) (Govt. of India)

4.     Scientific Reports (Nature Publishing Group)

5.     Frontiers Endocrinology

6.     Clinical Immunology(Elsevier)

7.     Immunobiology

8.     Acta Diabetologica (Springer)

9.     World Journal of Diabetes

10.  World Journal of Gastroenterology

11.  Endocrine Connections

12.  Endocrinology, Diabetes& Metabolism

13.  Indian Journal of MedicalResearch

14.  International Journal ofEndocrinology

15.  Heliyon (Cell Press)

16.  InternationalImmunopharmacology

17.  Experimental Eye Research

18.  J Pediatric Endocrinology

19.  Journal of Pediatric Genetics

20.  Annals of Neurosciences

21.  International Journal of Immunology and Immunotherapy

22.  Central European Journal of Immunology

23.  Archives of Medical Research

24.  BioMed Research International

25.  Indian Journal of Nephrology

26.  International Journal of Critical Care and Emergency Medicine

27.  Journal of Medical and Biological Science Research

28.  Journal of Immunological Sciences

29.  British Journal of Sports Medicine   

PUBLICATIONS:(H-INDEX: 40, as on July 2024)

(* First/Corresponding author): 34

1.     Saroha HS, Bhat S, Das L, Dutta P, Holick MF, *SachdevaN, Marwaha RK. Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine byupregulating genes promoting memory T cell responses. NPJ Vaccines. 2024 Jun20;9(1):114. doi: 10.1038/s41541-024-00909-w. (NS and RKM:Co-Correspondence).

2.     Kaur S, Kumari P, Singh G, Joshi N, Kaur T, Dhiman V, SinghG, Sachdeva N, Kumar D, Barnwal RP, Bhadada SK. Unveiling novel metabolic alterations inpostmenopausal osteoporosis and type 2 diabetes mellitus through NMR-basedmetabolomics: A pioneering approach for identifying early diagnostic markers. J Proteomics. 2024 Jun 30;302:105200. doi:10.1016/j.jprot.2024.105200. 

3.     Das L, Sachdeva N, Holick MF, Devnani M,Dutta P, Marwaha RK. Impact of BMI on serum 25-hydroxyvitamin D and1,25-dihydroxyvitamin D with calcifediol supplementation in young adults: alongitudinal study. Endocrine. 2024 Jun 11. doi:10.1007/s12020-024-03895-0.

4.     Malhotra B, Teja KVR, Masoodi SR, Das L, Mukherjee S,Rastogi A, Dutta A, Singhmar S, Sachdeva N, Marwaha RK, Dutta P.Normative Data on Dehydroepiandrosterone Sulphate (DHEAS) and its Attributes inHealthy Indian Children and Adolescents. Indian J Pediatr. 2024 Jun;91(6):617-619. doi:10.1007/s12098-023-04842-z.

5.     Chaudhary S, Walia R, Bhansali A, DayalD, Sachdeva N, Singh T, Bhadada SK. Basal and FSH-stimulated Inhibin B in PrecociousPuberty. Indian Pediatr. 2024 May 25:S097475591600643. Online ahead of print.

6.     Ravi Teja KV, Malhotra B, Vogel M, MarwahaRK, Aggarwal A, Pal R, Das L, Sachdeva N, Devi N, Bansal D, RastogiA, Sharma S, Gajinder D, Bhadada SK, Ghosh J, Monaghan PJ, Korbonits M, DuttaP. Normative data for insulin-like growth factor-1 (IGF-1) in healthy childrenand adolescents from India. J Clin Endocrinol Metab. 2024 May15:dgae340. doi: 10.1210/clinem/dgae340. 

7.     Lokesh MN, Kumar R, Jacob N, Sachdeva N,Rawat A, Yadav J, Dayal D. Supplementation of High-Strength Oral ProbioticsImproves Immune Regulation and Preserves Beta Cells among Children withNew-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo ControlTrial. IndianJ Pediatr. 2024Apr 1. doi: 10.1007/s12098-024-05074-5. 

8.    GuptaA, Mukherjee S, Kumar Bhadada S, Ram S, Pal R, Sachdeva N, Dutta P.Impact of short-termapplication of continuous glucose monitoring system(CGMS) on long-term glycemicprofile in adolescents and adults with type 1 diabetes mellitus: An open-labelrandomized control cross over study. Diabetes Res Clin Pract. 2024 Mar 12; 210:111610. doi:10.1016/j.diabres.2024.111610.

9.     Agrawal K, BasakP, Badal D, Dutta P, Walia R, *Sachdeva N. Effect ofneonatal BCG vaccination on the evolution of Hashimoto Thyroiditis. medRxiv,2024.02. 28.24303481

10.  De D, Shilpa S, Kumar S,Drenovska K, Mehta H, van Beek N, Sachdeva N, Fleva A, Shahid M,Handa S, Giannakou A, Naumova E, Mahajan R, Kyriakou A, Lesichkova S, LazaridouE, Radotra BD, Kishore K, Schmidt E, Vassileva S, Patsatsi A. Differences among Indian and Europeanpemphigus patients based on demographics, clinical parameters and propensityfor relapse: results of a prospective bicontinental cohort study. Eur J Dermatol. 2023 Dec 1;33(6):642-647. doi:10.1684/ejd.2023.4631.

11.   Das L, Holick MF, Sachdeva N,Bhadada SK, Singhmar S, Thakur N, Dutta P, Marwaha RK.
Efficacy, safety, anddose-response effects of calcifediol supplementation on 25-hydroxyvitamin D,parathyroid hormone, and 1,25-dihydroxyvitamin D levels in healthy adults: Anopen-label, interventional pilot study. Indian J Pharmacol. 2023Sep-Oct;55(5):286-292. doi: 10.4103/ijp.ijp_873_22

12.  Sachdeva M, Taneja S, *Sachdeva N. Stemcell-like memory T cells: Role in viral infections and autoimmunity. WorldJ Immunol 2023; 13(2): 11-22 [DOI: 10.5411/wji.v13.i2.11]

13.  Malhotra B, Teja KVR, MasoodiSR, Das L, Mukherjee S, Rastogi A, Dutta A, Singhmar S, Sachdeva N,Marwaha RK, Dutta P. Normative Data on Dehydroepiandrosterone Sulphate (DHEAS)and its Attributes in Healthy Indian Children and Adolescents. Indian JPediatr. 2023 Sep 15. doi: 10.1007/s12098-023-04842-z.

14.  Banerjee S, Nahar U, Dahiya D,Gupta R, Mukherjee S, Sachdeva N, Sood A, Dey P, Radotra B,Bhansali A. IL-17 A correlates with disease progression in papillarythyroid carcinoma. Diagn Pathol. 2023 Aug 10;18(1):93.

15.  Bhat S, Das L, Maheshwari D, Badal D, Sarkar R, Gupta M,Pandav SS, Padhi BK, Bhadada SK, Holick MF, Dutta P, *Sachdeva N,Marwaha RK. Effect of Calcifediol supplementation as add-on therapy on theimmune repertoire in recipients of the ChAdOx1 nCoV-19 vaccine: A prospectiveopen-label, placebo-controlled, clinical trial. Journal of Infection. May2023, 86 (5) e120-e122. doi:https://doi.org/10.1016/j.jinf.2023.03.004. (NS and RKM: Co-Correspondence)

16.  Kumar S, Randhawa MS, AnguranaSK, Nallasamy K, Bansal A, Kumar MR, Sachdeva N, Jayashree M. ClinicalProfile, Intensive Care Needs and Outcome of Children with DilatedCardiomyopathy Associated with Vitamin D Deficiency: A 5-year PICU Experience.Indian J Crit Care Med. 2023 Jul;27(7):510-514.

17.   Mukherjee S,Maheshwari D, Pal R, *Sachdeva N. Pancreatic fat in type 2diabetes: Causal or coincidental? World J Meta-Anal 2023; 11(3):68-78 [doi: 10.13105/wjma.v11.i3.68].

18.   SanjanG, Das L, Ahuja CK, Dhandapani S, Sachdeva N, Grover S, Dutta P. Impulse Control Disorders with Short-term Use ofCabergoline in Macroprolactinomas: A Prospective Study with a Brief Review ofLiterature. Neurol India. 2023;71(1):107-112.

19.   Chowdhary A, Gupta N, WursterS, Kumar R, Mohabir JT, Tatavarthy S, Mittal V, Rani P, Barman P, SachdevaN, Singh A, Sharma B, Jiang Y, Cuomo CA, Kontoyiannis DP. Multimodal analysis of the COVID-19-associatedmucormycosis outbreak in Delhi, India indicates the convergence of clinical andenvironmental risk factors. Mycoses. 2023 Feb 15. doi:10.1111/myc.13578.

20.   JayantSS, Gupta R, Rastogi A, Sachdeva N, Ram S, Dutta P, Bhansali A,Bhadada SK. Incidence and predictors of metabolic syndrome inAsian-Indians: a 10-year population-based prospective cohort study. Int J Diabetes Dev Ctries.2023:1-7. doi: 10.1007/s13410-023-01169-5. 

21.   Kaur G, Bhadada SK, SachdevaN, Saikia UN, Dahiya D, Seth S, Raik S, Behera A, Rao SD.
Establishment and characterization of long-term human primary parathyroidtumor subclones derived from Indian PHPT. 3 Biotech. 2023 May;13(5):161.

22.   Vinay K, Bhattachajee R,Bishnoi A, Kaushik A, Sachdeva N, Pal A, Narang T, Dogra S. Clinical and metabolic characteristics of males withearly-onset androgenetic alopecia. Indian J Dermatol VenereolLeprol. 2023 Jul-Aug;89(4):530-535.

23.   GuptaR, Jayant SS, Rastogi A, Bhadada SK, Bhansali A, Sachdeva N, Ram S.Incidence and risk factors for dysglycaemia inAsian-Indians: a 10-year population-based prospective cohort study. Postgrad Med J. 2023May 19;99(1169):176-182. 

24.   Aggarwal P, Seenivasagam RK,Sood A, Prashar S, Pathak P, Sachdeva N, Gupta P. Radioactive Iodine Uptake in Postoperative Seroma: A Causefor False Positivity. J Nucl Med Technol. 2023; 51: 68-69.

25.   Sehgal IS, Dhooria S, SachdevaN, Rudramurthy SM, Prasad KT, Muthu V, Aggarwal AN, Garg M, Chakrabarti A,Agarwal R. Role of serum procalcitonin in the diagnosis and monitoring oftreatment response in treatment-naïve subjects with chronic pulmonaryaspergillosis. Heliyon. 2023 Apr 7;9(4): e15356.

26.   BhalaviH, Shaw D, Mehta H, Narang T, Sachdeva N, Shafiq N, Rudramurthy SM,Dogra S. Correlation of plasma levels of itraconazole withtreatment response at 4 weeks in chronic dermatophytosis: Results of arandomised controlled trial. Mycoses. 2023; 66:281-288.

27.   Ashraf R, Mahajan R, Malik MA,Handa S, Sinha A, De D, Sachdeva N. Comparing the Effectiveness ofPropranolol versus Atenolol in Inducing Clinical Clearance in the Treatment ofInfantile Haemangioma: A Randomised Controlled Trial. Indian J Dermatol.2023 Mar-Apr;68(2):148-155. 

28.   Sharma RK,Sharma J, Kumar R, Badal D, Pattekar A, Sehgal S, Gupta A, Jain P, *Sachdeva N. TLR9 signalingactivation via direct ligation and its functional consequences in CD4+T cells. ScandJ Immunol. 2022; 96: e13214. doi:10.1111/sji.13214. (NS andRKS: Co-Correspondence)

29.   BanerjeeS, Nahar U, Dahiya D, Mukherjee S, Dey P, Gupta R, Radotra B, SachdevaN, Sood A, Bhadada SK, Bhansali A. Role of cytotoxic T cells and PD-1 immune checkpointpathway in papillary thyroid carcinoma. Front Endocrinol(Lausanne). 2022; 13: 931647.

30.   Reddy R, Dayal D, SachdevaN, Attri SV, Gupta VK. Combination therapy with lansoprazole and cholecalciferolis associated with a slower decline in residual beta-cell function and lowerinsulin requirements in children with recent onset type 1 diabetes: results ofa pilot study. Einstein (Sao Paulo). 2022;20: eAO0149.

31.   Rain M, Puri GD, Bhalla A,Avti P, Subramaniam B, Kaushal V, Srivastava V, Mahajan P, Singh M, Pandey N,Malhotra P, Goel S, Kumar K, Sachdeva N, Maity K, Verma P, Dixit N,Gupta SJ, Mehra P, Nadholta P, Khosla R, Ahuja S, Anand A. Effect of breathing intervention in patients with COVIDand healthcare workers. Front Public Health. 2022; 10: 945988.

32.   SharmaR, Handa S, Mahajan R, De D, Sachdeva N. Evaluating the Effect of Supplementation with Bacillusclausii on Therapeutic Outcomes in Atopic Eczema-Results of an Observer-BlindedParallel-Group Randomized Controlled Study. Indian J Dermatol. 2022;67:121-126. doi: 10.4103/ijd.ijd_587_21.

33.   ChaudharyS, Das L, Sharma N, Sachdeva N, Bhansali A, Dutta P. Utility of myxedema score as a predictor of mortality inmyxedema coma. J Endocrinol Invest. 2023; 46: 59-65.

34.   Kaur I, Suri V, SachdevaN, Rana SV, Medhi B, Sahni N, Ahire J, Singh A. Efficacy of multi-strain probiotic along with dietary andlifestyle modifications on polycystic ovary syndrome: a randomised,double-blind placebo-controlled study. Eur J Nutr. 2022 Jul20. doi: 10.1007/s00394-022-02959-z.

35.   KaurG, Bhadada SK, Santra M, Pal R, Sarma P, Sachdeva N, Dhiman V,Dahiya D, Saikia UN, Chakraborty A, Sood A, Prakash M, Behera A, Rao SD. Multi-level annotation of germline MEN1 variants ofsynonymous, non-synonymous and uncertain significance in Indian patients withsporadic primary hyperparathyroidism. J Bone Miner Res. 2022Jul 20. doi: 10.1002/jbmr.4653.

36.   ChaudharyS, Walia R, Bhansali A, Dayal D, Sachdeva N, Singh T, Bhadada SK. Unravelling a novel, promising and convenient tool fordifferential diagnosis of delayed puberty: GnRHa-stimulated inhibin B(GnRH-iB). J Endocrinol Invest. 2022; 45:2265-2273.

37.   Gupta S, Dayal D, Rohit MK,Gawalkar AA, Raj KM, Attri SV, Sachdeva N, Kaur H. Comprehensive assessment of cardiovascular disease risk inchildren with short stature due to isolated growth hormone deficiency: acase-control study. J Pediatr Endocrinol Metab. 2022 Jul 12;35(8):1059-1068. doi:10.1515/jpem-2021-0693. Print 2022 Aug 26

38.   DuttaS, Sachdeva N, Pal A, Ray P. Cerebrospinal fluid and plasma procalcitonin for thediagnosis of neonatal bacterial meningitis. J Paediatr Child Health.2022; 58(8):1425-1430.

39.   Jain K, Thakur V, Handa S,Thakur N, Shilpa, Sachdeva N, Mahajan R, De D. A randomised clinical trial to assess the adjuvantpotential of methotrexate to corticosteroids in mucosal or limitedmucocutaneous pemphigus vulgaris. Sci Rep. 2022 May9;12(1):7525. doi: 10.1038/s41598-022-11387-2

40.   Hr D, Praneeth K, Aggarwal A,Gupta SK, Sachdeva N. Seasonal variation and Incidence of rupture ofintracranial aneurysm: A prospective study and Literature review. Acta Neurol Taiwan.2022 Sep 30;31(3):137-145

41.   SinghN, Handa S, Mahajan R, Sachdeva N, De D. Comparison of the efficacy and cost-effectiveness of animmunologically targeted low-dose rituximab protocol with the conventionalrheumatoid arthritis protocol in severe pemphigus. Clin Exp Dermatol.2022;47(8):1508-1516.

42.   ValechaD, Lakshmi PVM, Sachdeva N, Kumar R. Association of birth weight with risk factors ofcardiovascular diseases: A birth cohort analysis from a rural area of NorthernIndia. Indian J Public Health. 2022; 66: 9-14.

43.   SharmaV, Sachdeva N, Gupta V, Nada R, Jacob J, Sahni D, Aggarwal A. CCR4+ monocytic myeloid-derived suppressor cells areassociated with the increased epithelial-mesenchymal transition in pancreaticadenocarcinoma patients. Immunobiology. 2022; 227(3):152210.

44.   JayantSS, Gupta R, Rastogi A, Agrawal K, Sachdeva N, Ram S, Dutta P,Bhadada SK, Bhansali A. Abdominal obesity and incident cardio-metabolic disordersin Asian-Indians: A 10-years prospective cohort study. Diabetes Metab Syndr.2022;16(2):102418.

45.   BhatV, Saini SS, Sachdeva N, Walia R, Sundaram V, Dutta S. Adrenocortical Dysfunctions in Neonatal Septic Shock. Indian J Pediatr. 2022Jan 29. doi: 10.1007/s12098-021-03955-7.

46.   SriramN, Madaan P, Malhi P, Sachdeva N, Negi S, Das J, Kumar R, Sahu JK,Singhi P. Evaluation of Hyperandrogenism in Children with AutismSpectrum Disorder. Indian J Pediatr. 2022 Jan 28. doi: 10.1007/s12098-022-04080-9

47.   Singh I, Reddy C, Saini AG,Dayal D, Sharawat I, Kasinathan A, Sachdeva N, Attri S, Sankhyan N.Prevalence of peripheral neuropathy and associatedrisk factors in children with type 1 diabetes. Prim Care Diabetes.2022: S1751-9918(22)00003-1.

48.   Badal D, *SachdevaN, Maheshwari D, Basak P. Role of nucleic acid sensing in the pathogenesisof type-1 diabetes. World J Diabetes. 2021 Oct15;12(10):1655-1673. (DB and NS, equal first authors).

49.   Rao H, Dutta S, Menon P, AttriS, Sachdeva N, Malik M. Procalcitonin and C-reactive protein for diagnosingpost-operative sepsis in neonates. J Paediatr Child Health.2021 Oct 12. doi: 10.1111/jpc.15774.

50.   Singh P, Bhadada SK, Arya AK,Saikia UN, Sachdeva N, Dahiya D, Kaur J, Brandi ML, Rao SD. Aberrant epigenetic alteration of PAX1 expression contributes toparathyroid tumorigenesis. J Clin Endocrinol Metab. 2021 Aug 28: dgab626.doi: 10.1210/clinem/dgab626. 

51.   Das L, Dutta P, Walia R,Mukherjee S, Suri V, Puri GD, Mahajan V, Malhotra P, Chaudhary S, Gupta R,Jayant SS, Agrawal K, Kumar V, Sachdeva N, Rastogi A, Bhadada SK,Ram S, Bhansali A. Spectrum of Endocrine Dysfunction and Association withDisease Severity in Patients With COVID-19: Insights from a Cross-Sectional,Observational Study. Front Endocrinol (Lausanne). 2021 Jul 2; 12:645787.doi: 10.3389/fendo.2021.645787.

52.   Bhagat H, Sharma T, Mahajan S,Kumar M, Saharan P, Bhardwaj A, Sachdeva N, Gandhi K, Jangra K,Panda NB, Singla N, Kishore K, Singh N. Intravenous versus inhalationalanesthesia trial for outcome following intracranial aneurysm surgery: Aprospective randomized controlled study. Surg Neurol Int. 2021 Jun 21;12:300. doi: 10.25259/SNI_342_2021.

53.   KumarS, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemiccontrol in children with new-onset Type 1 diabetes mellitus: a randomized,double-blind, placebo-controlled pilot study. Pediatr Diabetes. 2021Jun 26. doi: 10.1111/pedi.13244.

54.   Singh P, Bhadada SK, Dahiya D,Saikia UN, Arya AK, Sachdeva N, Kaur J, Behera A, Brandi ML, RaoSD. GCM2 Silencing in Parathyroid Adenoma is associatedwith Promoter Hypermethylation and Gain of Methylation on Histone 3. J Clin Endocrinol Metab.2021 Jun 2: dgab374. doi: 10.1210/clinem/dgab374.

55.   ChaudharyS, Walia R, Bhansali A, Dayal D, Sachdeva N, Singh T, Bhadada SK. FSH stimulated inhibin B (FSH-iB): A novel marker for theaccurate prediction of pubertal outcome in delayed puberty. J Clin Endocrinol Metab.2021 May 19: dgab357. doi: 10.1210/clinem/dgab357

56.   WaliaR, Dutta A, Gupta N, Bhansali A, Pivonello R, Ahuja CK, Dhandapani S, Dutta P,Bhadada SK, Simeoli C, Hajela A, Sachdeva N, Saikia UN. Etiology-, Sex-, and Tumor Size-Based Differences inAdrenocorticotropin-Dependent Cushing Syndrome. Endocr Pract. 2021May;27(5):471-477. doi: 10.1016/j.eprac.2020.11.014. Epub 2020 Dec 15. PMID: 33853717

57.   Khaire NS, Jindal N,Yaddanapudi LN, Sachdev S, Hans R, Sachdeva N, Singh MP, Agarwal A,Mukherjee A, Kumar G, Sharma RR, Suri V, Puri GD, Malhotra P. Use ofconvalescent plasma for COVID-19 in India: A review & practical guidelines. Indian J Med Res. 2021 Jan & Feb;153(1& 2):64-85. doi: 10.4103/ijmr.IJMR_3092_20

58.   Ravi RD, Kalra J, SrinivasanR, Bagga R, Jain V, Suri V, Sachdeva N. A Randomized Clinical Trialof Levonorgestrel Intrauterine System with or without Metformin for Treatmentof Endometrial Hyperplasia without Atypia in Indian Women. Asian Pac JCancer Prev. 2021 Mar 1;22(3):983-989.

59.   Guliani A, De D, Handa S,Mahajan R, Sachdeva N, Radotra BD, Kishore K. Response to areader's query on CD19+ B cell as predictor of relapse in pemphigus vulgaris. IndianJ Dermatol Venereol Leprol. 2021 Mar-Apr;87(2):238-239.

60.   AggarwalA, Ram S, Garg A, Pal R, Bhansali A, Singh P, Sharma S, Thakur JS, SachdevaN, Bhadada SK. Metabolic Bone Profile of Healthy Adult North IndianPopulation from Chandigarh Urban Bone Epidemiological Study (CUBES). Indian J Clin Biochem. 2021 Jan;36(1):67-73. doi:10.1007/s12291-019-00857-6.

61.   AggarwalA, Pal R, Bhadada SK, Ram S, Garg A, Bhansali A, Singh P, Thakur JS, Singh T, SachdevaN, Rao SD. Bone mineraldensity in healthy adult Indian population: the Chandigarh Urban BoneEpidemiological Study (CUBES). Arch Osteoporos. 2021Jan 21;16(1):17. doi: 10.1007/s11657-020-00868-4.

62.   MoudgilS, Mahajan R, Narang T, Sachdeva N, Dayal D, Dogra S. Central obesity and dyslipidemia in pediatricpatients with psoriasis: An observational study from India. J Am Acad Dermatol. 2021 Jan 9:S0190-9622(21)00091-8.

63.   Pal R,Aggarwal A, Sachdeva N, Ram S, Garg A, Bhansali A, Bhadada SK. Age- and sex-specific concentrations of boneremodeling markers in healthy Indian adults with and without vitamin Ddeficiency. Arch Osteoporos. 2021Jan 7;16(1):10.

64.  PalR, *Sachdeva N, Mukherjee S, Suri V, Zohmangaihi D, Ram S, Puri GD,Bhalla A, Soni SL, Pandey N, Bhansali A, Bhadada SK. Impaired anti-SARS-CoV-2 antibody response in non-severeCOVID-19 patients with diabetes mellitus: A preliminary report. DiabetesMetab Syndr. 2020 Dec 25;15(1):193-196. (NS and SKB:Co-Correspondence)

65.  Pal R, Sachdeva N, Bhansali A, Sharma A,Walia R. Prevalence ofDepression and Psychological Distress and Perturbations of Cortisol Dynamics inAttendants of Hospitalized Patients: An Observational Pilot Study. Cureus. 2020 Dec 13;12(12): e12067. doi: 10.7759/cureus.12067.

66.  Katoch T, Singh A, Suri V, Sethi S, Sachdeva N, Naseem S. Diagnostic performance of biomarkers in maternal sepsis: Aprospective observational study. Int J Gynaecol Obstet. 2020 Dec 11. doi:10.1002/ijgo.13525.

67.   DayalD, Panigrahi I, Varma T, Gupta S, Gupta A, Kumar R, Sachdeva N. Ten-year use of recombinant parathyroid hormone for thetreatment of hypoparathyroidism in a boy with partial Jacobsen syndrome. Pediatr EndocrinolDiabetes Metab. 2021;27(1):57-61.

68.  Rastogi A, Bhansali A, Khare N, Suri V, YaddanapudiN, Sachdeva N, Puri GD, Malhotra P. Short term,high-dose vitamin D supplementation for COVID-19 disease: a randomised,placebo-controlled, study (SHADE study). Postgrad Med J. 2020 Nov12:postgradmedj-2020-139065. doi: 10.1136/postgradmedj-2020-139065.

69.  BasakP, *SachdevaN, *Dayal D. Can BCG vaccine protectagainst COVID-19 via trained immunity and tolerogenesis? BioEssays 2020;doi: 10.1002/bies.202000200 (NS and DD: Co-Correspondence)

70.  Jacob N, Jaiswal S,Maheshwari D, Nallabelli N, Khatri N, Bhatia A, Bal A, Malik V, Verma S, KumarR and Sachdeva N.^*Butyrate induced Tregs are capable of migration from the GALT to thepancreas to restore immunological tolerance during type-1 diabetes. Scientific Reports 2020; 10:19120.https://doi.org/10.1038/s41598-020-76109-y

71.   AgarwalA, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P and PLACID TrialCollaborators. Convalescent plasma in the management of moderate covid-19 inadults in India: open label phase II multicentre randomised controlled trial(PLACID Trial). British Medical Journal 2020;371:m3939.http://dx.doi.org/10.1136/bmj.m3939.

72.   Walia R, Gupta R, Bhansali A, Pivonello R, Kumar R,Singh H, Ahuja C, Chhabra R, Singh A, Dhandapani S, Sahoo S, Rana N, Vatsa R,Dutta P, Bhadada SK, Sachdeva N, Mittal BR, Nahar U, Shukla J.Molecular Imaging Targeting Corticotropin Releasing Hormone Receptor forCorticotropinoma: A Changing Paradigm. J Clin EndocrinolMetab. 2021Mar 25;106(4):e1816-e1826.

73.   SehgalIS, Dhooria S, Prasad KT, Muthu V, Sachdeva N, Bhadada SK, AggarwalAN, Garg M, Chakrabarti A, Agarwal R. Prevalence of Vitamin D Deficiency inTreatment-Naïve Subjects with Chronic Pulmonary Aspergillosis. J Fungi(Basel). 2020 Oct 1;6(4): E202.

74.  Raj KAP, Handa S, Narang T, Sachdeva N, Mahajan R. Correlation of serum vitamin D levels with severity ofpediatric atopic dermatitis and the impact of vitamin D supplementation ontreatment outcomes. J Dermatolog Treat. 2020 Oct 12:1-4. doi:10.1080/09546634.2020.1818677.

75.   SharmaSK, Jain S, Bahl P, Potturi P, Rathi M, Naidu S, Sachdeva N, DhirV, Jain S. Ovarian dysfunction with moderate-dose intravenous cyclophosphamide(modified NIH regimen) and mycophenolate mofetil in young adults with severelupus: a prospective cohort study. Arthritis Res Ther. 2020 Aug14;22(1):189.

76.  Singh P, BhadadaSK, Dahiya D, Arya AK, Saikia UN, SachdevaN, Kaur J, Brandi ML, Rao DS. Reduced Calcium Sensing Receptor(CaSR) Expression Is Epigenetically Deregulated in Parathyroid Adenomas. The Journal of Clinical Endocrinology &Metabolism 2020; 105 (9), dgaa419

77.  BadalD, Dayal D, Singh G, *Sachdeva N. Role of DNA-LL37 complexes in theactivation of plasmacytoid dendritic cells and monocytes in subjects with type1 diabetes. ScientificReports 2020; 10 (1), 1-19. doi: 10.1038/s41598-020-65851-y

78.  Aradhya AS, Sundaram V, Sachdeva N, Dutta S, Saini SS, Kumar P. Lowvasopressin and progression of neonatal sepsis to septic shock: a prospectivecohort study. Eur J Pediatr. 2020; 20 (2): 1-9.

79.  Guliani A, De D, Handa S, Mahajan R, Sachdeva N, Radotra BD,Kishore K. Identification of clinical andimmunological factors associated with clinical relapse of pemphigus vulgaris inremission. Indian J Dermatol Venereol Leprol. 2020; 86 (3), 233.

80.  AK Arya, PSingh, UN Saikia, NSachdeva, D Dahiya, A Behera, Sudhaker D Rao, SK Bhadada. Dysregulatedmitogen-activated protein kinase pathway mediated cell cycle disruption insporadic parathyroid tumors. Journalof Endocrinological Investigation 2020; 43 (2): 247-253.

81.  Makkar JK,Gourav KKP, Jain K, Singh PM, Dhatt SS, Sachdeva N, Bhadada S. TransforaminalVersus Lateral Parasagittal Versus Midline Interlaminar Lumbar Epidural SteroidInjection for Management of Unilateral Radicular Lumbar Pain: A RandomizedDouble-Blind Trial. Pain Physician. 2019; 22(6):561-573.

82.  Walia R, Aggarwal A, Bhansali A, Aggarwal A, Varma N, Sachdeva N, Khandelwal N, Bansal D. Acquired neuro-secretory defect ingrowth hormone secretion due to Imatinib mesylate and the efficacy of growthhormone therapy in children with chronic myeloid leukemia. Pediatr Hematol Oncol 2020; 37 (2): 99-108.

83.  Jain N, Kumar KM, Sachdeva N, Bhansali A, Walia R. Demystifying"Steroid Withdrawal" During Remission in Cushing's Disease: Is MineralocorticoidReplacement the Answer? Indian J Endocrinol Metab. 2019; 23(4):456-459.

84.  Sachdeva G,Gainder S, Suri V, Sachdeva N, Chopra S. Comparison of the Different PCOSPhenotypes Based on Clinical Metabolic, and Hormonal Profile, and theirResponse to Clomiphene. Indian J Endocrinol Metab. 2019; 23(3):326-331.

85.  Chandel D,Sharma M, Chawla V, Sachdeva N, Shukla G. Isolation, characterization andidentification of antigenotoxic and anticancerous indigenous probiotics andtheir prophylactic potential in experimental colon carcinogenesis. Scientific Reports. 2019;9(1):14769.

86.  Sachdeva G,Gainder S, Suri V, Sachdeva N, Chopra S. Comparison of Clinical,Metabolic, Hormonal, and Ultrasound Parameters among the ClomipheneCitrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary SyndromeWomen. J Hum Reprod Sci. 2019;12(3):216-223.

87.  Sachdeva G,Gainder S, Suri V, Sachdeva N, Chopra S. Prediction of Responsiveness toClomiphene Citrate in Infertile Women with PCOS. J Reprod Infertil. 2019;20(3):143-150.

88.  Dutta P, Hajela A, Gupta P, Rai A, Sachdeva N, Mukherjee KK,Pathak A, Dhandapani S. The predictors of recovery fromdiabetes mellitus following neurosurgical treatment of acromegaly: Aprospective study over a decade. NeurolIndia. 2019; 67(3):757-762.

89.  Shah J,Mandavdhare HS, Sachdeva N, Prasad KK, Singh H, Dutta U, Sharma V. HbA1clevels at presentation do not impact the clinical presentation or outcomes inabdominal tuberculosis. Int J Mycobacteriol. 2019;8(2):162-165.

90.  Sachdeva G,Gainder S, Suri V, SachdevaN, Chopra S. Obese and Non-obese PolycysticOvarian Syndrome: Comparison of Clinical, Metabolic, Hormonal Parameters, andtheir Differential Response to Clomiphene. Indian J Endocrinol Metab. 2019;23(2):257-262.

91.  Jarial KDS,Bhansali A, Mukherjee KK, Pal R, Gupta V, Sharma A, Vasishta RK, SukumarSP, Sachdeva N, Walia R. Prolactin-adjusted ACTH Ratio in PredictingLateralization of ACTH Source During Simultaneous Bilateral Inferior PetrosalSinus Sampling in Patients with Cushing's Disease. Indian J EndocrinolMetab. 2019;23(1):56-59. 

92.  Raviteja KV, Kumar R, Dayal D, Sachdeva N. Clinicalefficacy of Professional Continuous Glucose Monitoring in improving glycemiccontrol among children with Type 1 Diabetes Mellitus: An Open-label RandomizedControl Trial. Scientific Reports. 2019; 9(1):6120.

93.  Shekhawat VS,Bhansali S, Dutta P, Mukherjee KK, Vaiphei K, Kochhar R, Sinha SK, SachdevaN, Kurpad AV, Bhat K, Mudaliar S, Bhansali A. Glucose-dependent InsulinotropicPolypeptide (GIP) Resistance and β-cell Dysfunction Contribute toHyperglycaemia in Acromegaly. Scientific Reports. 2019;9(1):5646.

94.  Panjiyar RP,Dayal D, Attri SV, Sachdeva N, Sharma R, Bhalla AK. Sustainedserum 25-hydroxyvitamin D concentrations for one year with cholecalciferolsupplementation improves glycaemic control and slows the decline of residual βcell function in children with type 1 diabetes. PediatrEndocrinol Diabetes Metab. 2018; 2018(3):111-117.

95.  Nampoothiri RV,Duseja A, Rathi M, Agrawal S, Sachdeva N, Mehta M, Dhaliwal HS, DhimanRK, Chawla Y. Renal Dysfunction in PatientsWith Nonalcoholic Fatty Liver Disease is Related to the Presence of DiabetesMellitus and Severity of Liver Disease. J Clin Exp Hepatol. 2019;9(1):22-28.

96.  Paul M, Dayal D, Bhansali A,*Sachdeva N. "Characterization of proinsulin-specific regulatory T cells in type1 diabetes at different ages of onset" PediatrDiabetes 2019;20 (3): 271-281.

97.  Paul M, Dayal D, Bhansali A,Dhaliwal L, *Sachdeva N. Invitro assessment of cordblood derived proinsulin-specific regulatory T cells for cellular therapy intype 1 diabetes. Cytotherapy2018; 20:1355-70.

98.  Banavath LN,Kumar R, Dayal D, Yadav J, Sachdeva N, Mathew JL, Vaidya PC, Singh M. Glucoseintolerance in children with cystic fibrosis: a developing country'sperspective. J Pediatr Endocrinol Metab. 2018;31(10):1139-1146.

99.  Sharma RK,Sehgal S, Sachdeva N, Kumar R, Gupta A. Direct Engagement of TLR9 Ligandwith T Helper Cells Leads to Cell Proliferation & Up-regulation ofCytokines. Immunol Invest. 2019;48(1):79-95.

100.     Sharma RK, Sharma J, KhanZK, Pattekar A, Gupta V, Bansal R, Sharma K, Aggarwal AN, Gupta A, *Sachdeva N. Diminished TLR2-TLR9mediated CD4+ T cell responses are associated with increased inflammation inintraocular tuberculosis. Sci Rep. 2018 Sep 14;8(1):13812.

101.     Gupta P, Rai A,Mukherjee KK, Sachdeva N, Radotra BD, Punia RPS, Vashista RK, Hota D,Srinivasan A, Dhandapani S, Gupta SK, Bhansali A, Dutta P. Imatinib Inhibits GHSecretion from Somatotropinomas. Front Endocrinol (Lausanne). 2018;9:453.

102.     SinghRR, Walia R, Sachdeva N, Bhalla A,Singh A, Singh V. Relative adrenal insufficiency in cirrhotic patients withascites (hepatoadrenal syndrome). Dig Liver Dis.2018; 50: 1232-37.

103.     Sharma RK, Gupta V, BansalR, Sharma K, Gupta A, *Sachdeva N.Immune profiling of T cells infiltrating vitreous humor in tubercular uveitis. Immunol Invest. 2018 Aug;47(6):615-631. doi: 10.1080/08820139.2018.1470640.

104.     Jarial KDS, Bhansali A, GuptaV, Singh P, Mukherjee KK, Sharma A, Vashishtha RK, Sukumar SP, Sachdeva N, Walia R. Diagnostic accuracy and comparison ofBIPSS in response to lysine vasopressin and hCRH. Endocr Connect. 2018;7(3):425-432.

105.     RameshbabuM, Sundaram V, Sachdeva N, Walia R,Saini SS, Dutta S. Association between plasma cortisol and death orvasopressor refractory hypotension in preterm neonates: a prospective, cohortstudy. JPerinatol. 2018; 38(6):672-680.

106.     Balachandran B, MukhopadhyayK, Sachdeva N, Walia R, Attri SV. Randomised controlled trial ofdiazoxide for small for gestational age neonates with hyperinsulinaemichypoglycaemia provided early hypoglycaemic control without adverse effects. Acta Paediatr. 2018;107(6):990-995.

107.     Agarwal R, Sehgal IS, DhooriaS, Aggarwal AN, Sachdeva N, BhadadaSK, Garg M, Behera D, Chakrabarti A. Vitamin D levels in asthmatic patients with and withoutallergic bronchopulmonary aspergillosis. Mycoses. 2018; 61(6):344-349.

108.     Daroach M, Narang T, SaikiaUN, Sachdeva N, Sendhil Kumaran M. Correlation of vitamin D and vitaminD receptor expression in patients with alopecia areata: a clinical paradigm. Int J Dermatol. 2018;57(2):217-222.

109.     JarialKDS, Bhansali A, Mukherjee KK, Pal R, Sharma A, Vashishtha RK, Sukumar SP, Sachdeva N, Walia R. Utility of a single late-night plasmacortisol and ACTH for the diagnosis of Cushing syndrome. Endocr Pract. 2018;24(2):156-162.

110.     PaulM, Badal D, Jacob N, Dayal D, Kumar R, Bhansali A, Bhadada SK, *Sachdeva N. Pathophysiologicalcharacteristics of preproinsulin-specific CD8+ T cells in subjects withjuvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study. Pediatr Diabetes.2018; 19(1):68-79.

111.     Sharma RK, Gupta A, Kamal S,Bansal R, Singh N, Sharma K, Virk S, *SachdevaN. Role of regulatory T cells in tubercular uveitis. Ocular Immunology & Inflammation, 2018; 26(1):27-36.

112.     AbdulAJ, Ghai B, Bansal D, Sachdeva N,Bhansali A, Dhatt SS. Hypothalamic Pituitary Adrenocortical Axis Suppressionfollowing a Single Epidural Injection of Methylprednisolone Acetate. Pain Physician. 2017;20(7):E991-E1001.

113.     BadalD, Kumar R, Paul M, Dayal D, Bhansali A, Bhadada SK, Kumar R, *Sachdeva N. Peripheralblood mononuclear cells of patients with latent autoimmune diabetes secretehigher levels of pro- & anti-inflammatory cytokines compared to those withtype-1 diabetes mellitus following in vitro stimulation with β-cellautoantigens. Indian J Med Res. 2017; 145(6):767-776.

114.     Tenneti N, Dayal D, Sharda S,Panigrahi I, Didi M, Attri SV, SachdevaN, Bhalla AK. Concentrations of leptin, adiponectin and other metabolicparameters in non-obese children with Down syndrome. J Pediatr Endocrinol Metab.2017; 30(8):831-837.

115.     SharmaV, Mandavdhare HS, Kumar A, Sharma R, SachdevaN, Prasad KK, Rana SS. Prevalence and clinical impact of vitamin D deficiency onabdominal tuberculosis. Ther Adv Infect Dis. 2017; 4:83-86.

116.     AryaAK, Bhadada SK, Singh P, Sachdeva N,Saikia UN, Dahiya D, Behera A, Bhansali A, Rao SD. Promoter hypermethylation inactivates CDKN2A, CDKN2B andRASSF1A genes in sporadic parathyroid adenomas. Sci Rep. 2017;7(1):3123

117.     RahamanAS, De D, Handa S, Pal A, Sachdeva N,Ghosh T, Kamboj P. What is normal insulin-like growth factor-1 level? J Am Acad Dermatol.2017; 76(6): e225.

118.     SukumarSP, Bhansali A, Sachdeva N, AhujaCK, Gorsi U, Jarial KD, Walia R. Diagnostic utility of testosterone priming prior todynamic tests to differentiate constitutional delay in puberty from isolatedhypogonadotropic hypogonadism. Clin Endocrinol (Oxf). 2017; 86(5):717-724.

119.     RanaSV, Malik A, Bhadada SK, Sachdeva N,Morya RK, Sharma G. Malabsorption, Orocecal Transit Time and Small IntestinalBacterial Overgrowth in Type 2 Diabetic Patients: A Connection. Indian J ClinBiochem. 2017; 32:84-89.

120.     GhaiB, Bansal D, Kanukula R, Gudala K, SachdevaN, Dhatt SS, Kumar V. Vitamin D Supplementation in Patients with Chronic LowBack Pain: An Open Label, Single Arm Clinical Trial. Pain Physician. 2017; 20: E99-E105.

121.     BhansaliS, Dutta P, Kumar V, Yadav MK, Jain A, Mudaliar S, Bhansali S, Sharma RR, JhaV, Marwaha N, Khandelwal N, Srinivasan A, SachdevaN, Hawkins M, Bhansali A. Efficacy of Autologous Bone Marrow-Derived MesenchymalStem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: ARandomized, Placebo-Controlled Comparative Study. Stem Cells Dev. 2017 26(7):471-481.

122.     DhibarDP, Sharma YP, Bhadada SK, Sachdeva N,Sahu KK. Association of Vitamin D Deficiency with Coronary ArteryDisease. JClin Diagn Res. 2016; 10: OC24-OC28.

123.     Rana S, Morya RK, Malik A,Bhadada SK, Sachdeva N, Sharma G. A relationship between vitamin D,parathyroid hormone, calcium levels and lactose intolerance in type 2 diabeticpatients and healthy subjects. Clin Chim Acta.2016; 462:174-177.

124.     Harnot J, Verma S, Singhi S,Sankhyan N, Sachdeva N, Bharti B. Comparison of 300,000 and600,000 IU Oral Vitamin-D Bolus for Vitamin-D Deficiency in YoungChildren. IndianJ Pediatr. 2017; 84:111-116.

125.     RahamanSM, De D, Handa S, Pal A, Sachdeva N,Ghosh T, Kamboj P. Association of insulin-like growth factor (IGF)-1 genepolymorphisms with plasma levels of IGF-1 and acne severity. J Am Acad Dermatol. 2016; 75:768-73.

126.     NagpalM, De D, Handa S, Pal A, Sachdeva N.Insulin Resistance and MetabolicSyndrome in Young Men with Acne. JAMA Dermatol. 2016;152:399-404.

127.     Sindhuja L, Dayal D, Sodhi KS,Sachdeva N, Bhattacharya A. Thyroid dysfunction and developmentalanomalies in first degree relatives of children with thyroid dysgenesis. World J Pediatr. 2016; 12:215-8.

128.      Aggarwal A, Yadav AK,Ramachandran R, Kumar V, Kumar V, Sachdeva N, Khandelwal N, Jha V. Bioavailablevitamin D levels are reduced and correlate with bone mineral density andmarkers of mineral metabolism in adults with nephrotic syndrome. Nephrology(Carlton). 2016; 21:483-9.

129.      Mishra A, Dayal D, Sachdeva N, Attri SV. Effect of6-months' vitamin D supplementation on residual beta cell function in childrenwith type 1 diabetes: a case control interventional study. J PediatrEndocrinol Metab. 2016; 29(4):395-400.

130.     Dayal D, Sachdeva N. Preservation of Residual Beta CellFunction with Vitamin D Supplementation in Type 1 Diabetes. Immunoendocrinology.2015; 2: e1093. doi: 10.14800/ie.1093.

131.     Dayal D, Didel SR, Agarwal S, Sachdeva N, Singh M. Acute Hypercalcaemia andHypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis. J Clin Diagn Res. 2015;9(10):SD03-4.

132.      Ghai B, Bansal D, Kapil G, Kanukula R, Lavudiya S, Sachdeva N. High Prevalence of Hypovitaminosis Din Indian Chronic Low Back Patients. Pain Physician. 2015; 18(5):E853-62.

133.     Paul M, Jacob N, *Sachdeva N. Regulatory T cells in treatment of type-1 diabetes: types and approaches.Diabetes Res Open J. 2015; 1: 54-66.

134.     *Sachdeva N. Epitope specific T cells in type 1 diabetes: Fromdetection to immunotherapy. Immunoendocrinology2015; 2 (2): e760. doi: 10.14800/Immunoendocrinology.760.

135.     *Sachdeva N, Paul M,Badal D, Kumar R, Jacob N, Dayal D, Bhansali A, Arora SK, Bhadada SK. Preproinsulin specific CD8+ T cells in subjects withlatent autoimmune diabetes show lower frequency and differentpathophysiological characteristics than those with type 1 diabetes. ClinImmunol. 2015; 157:78-90.

136.      Dutta P, Hajela A, Pathak A, Bhansali A, Radotra BD, Vashishta RK,Korbonits M, Khandelwal N, Walia R, Sachdeva N, Singh P, MurlidharanR, Devgun JS, Mukherjee KK. Clinical profile and outcome ofpatients with acromegaly according to the 2014 consensus guidelines: Impact ofa multi-disciplinary team. Neurol India. 2015; 63:360-8.

137.      Dayal D, Sharma S, Sachdeva N, Bhalla AK, Attri SV. Efficacy ofinsulin detemir compared to insulin NPH on glycemic control in Indian childrenwith type 1 diabetes. Journal ofDiabetology, June 2014; 2:2

138.      Valiathan R, Deeb K, Diamante M, Ashman M, SachdevaN, Asthana D. Reference ranges of lymphocytesubsets in healthy adults and adolescents with special mention of T cellmaturation subsets in adults of South Florida. Immunobiology.2014; 219:487-96.

139.      Sooragonda B, Bhadada SK, Shah VN, Malhotra P,Ahluwalia J, Sachdeva N. Effect of Vitamin D Replacement onHemoglobin Concentration in Subjects with Concurrent Iron-Deficiency Anemia andVitamin D Deficiency: A Randomized, Single-Blinded, Placebo-Controlled Trial. Acta Haematol.2014 8; 133:31-35.

140.      Dayal D, Kumar S, Sachdeva N, Kumar R,Singh M, Singhi S. Fall in Vitamin D Levels duringHospitalization in Children. Int J Pediatr. 2014;2014:291856. 

141.     AryaAK, *Sachdeva N. Changes in Plasma Intact ParathyroidHormone Levels Following 24-Hour Incubation at Room Temperature as Determinedby Roche Electrochemiluminescence PTH Immunoassay. Clin Lab. 2014; 60:689-92.

142.      Walia R, Bhansali A,Ravikiran M, Ravikumar P, Bhadada SK, Shanmugasundar G, Dutta P, SachdevaN. High prevalence of cardiovascularrisk factors in Asian Indians: a community survey - Chandigarh Urban DiabetesStudy (CUDS). Indian J Med Res. 2014; 139:252-9.

143.      Palikhe G, Gupta R, BeheraBN, Sachdeva N, Gangadhar P, Bhansali A. Efficacy of Laparoscopic SleeveGastrectomy and Intensive Medical Management in Obese Patients with Type 2Diabetes Mellitus. Obes Surg. 2014; 24:529-35.

144.      Bhansali A, AP, Walia R, Bhansali S, Gupta V, Jain A, Sachdeva N, Sharma RR, Marwaha N,Khandelwal N. Efficacy and Safety ofAutologous Bone Marrow Derived Stem Cell Transplantation in patients with Type2 Diabetes mellitus: A randomized placebo-controlled study. CellTransplant. 2014; 23:1075-85.

145.      Varshney S, Bhadada SK, SachdevaN, Arya AK, Saikia UN, Behera A, Rao SD. Methylation status of the CpGislands in vitamin d and calcium-sensing receptor gene promoters does notexplain the reduced gene expressions in parathyroid adenomas. JClin Endocrinol Metab. 2013; 98: E1631-5.

146.      Devidayal, Singh MK, Sachdeva N,Singhi S, Attri SV, Jayashree M, Bhalla AK. Vitamin D levels during andafter resolution of ketoacidosis in children with new onset Type 1 diabetes. DiabetMed. 2013; 30: 829-34.

147.      Varshney S,Bhadada SK, Saikia UN, Sachdeva N, Behera A, Arya AK, Sharma S, BhansaliA, Mithal A, Rao DS. Simultaneous ExpressionAnalysis of Vitamin D Receptor, Calcium Sensing Receptor, Cyclin D1 and PTH inSymptomatic Primary Hyperparathyroidism in Asian Indians. EurJ Endocrinol. 2013; 169:109-16.

148.      Thirunavakkarasu K, Dutta P, SridharS, Dhaliwal L, Prashad GR, Gainder S, Sachdeva N, Bhansali A. Macroprolactinemiain hyperprolactinemic infertile women. Endocrine.2013; 44:750-5.

149.      Chopra A,Tuteja S, Sachdeva N, Bhasin KK, Bhalla V, Suri CR. CdTenanobioprobe based optoelectrochemical immunodetection of diabetic markerHbA1c. Biosens Bioelectron. 2013; 44:132-5.

150.      Rastogi A,Bhansali A, Dutta P, Singh P, Vijaivergiya R, Gupta V, Sachdeva N, BhadadaSK, Walia R. A comparison between intensiveand conventional cabergoline treatment of newly diagnosed patients withmacroprolactinoma. Clin Endocrinol (Oxf). 2013; 79:409-15.

151.      Narayanan KR,Bansal D, Walia R, Sachdeva N, Bhansali A, Varma N, Marwaha RK. Growthfailure in children with chronic myeloid leukemia receiving imatinib is due todisruption of GH/IGF-1 axis. Pediatr Blood Cancer. 2013;60:1148-53.

152.      Dayal D,Malhi P, Kumar Bhalla A, Sachdeva N, Kumar R. Psychomotorretardation in a girl with complete growth hormone deficiency. PediatrEndocrinol Diabetes Metab. 2013; 20:23-26.

153.      Sridhar S, Walia R,Sachdeva N, Bhansali A. Effectof pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus:A randomized double-blind placebo-controlled study. Clin Endocrinol (Oxf).2013, 78: 454-9.

154.      Singh PK, Hota D,Dutta P, Sachdeva N, Chakrabarti A,Srinivasan A, Singh I, Bhansali A. Pantoprazole Improves GlycemicControl in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-ControlledTrial. J Clin Endocrinol Metab. 2012, 97: E2105-8.

155.      Das S,Bhansali A, Dutta P, Aggarwal A, Bansal MP, Garg D, Ravikiran M, Walia R,Upreti V, Ramakrishnan S, Sachdeva N, Bhadada SK. Persistenceof goitre in the post-iodization phase: micronutrient deficiency or thyroidautoimmunity? Indian J Med Res. 2011; 133:103-9.

156.      Sachdeva M, Fischl MA, Pahwa R, Sachdeva N, Pahwa S. Immune Exhaustion Occurs Concomitantly With ImmuneActivation and Decrease in Regulatory T Cells in Viremic ChronicallyHIV-1-Infected Patients. JAcquir Immune Defic Syndr. 2010, 54:447-54.

157.     Ravikiran M, Bhansali A, Ravikumar P, Bhansali S, Dutta P, Thakur JS, SachdevaN, Bhadada S, Walia R. Prevalence and risk factors ofmetabolic syndrome among Asian Indians: A community survey. Diabetes ResClin Pract. 2010, 89:181-8.

158.     Kumar PR, Bhansali A, Ravikiran M, Bhansali S, Dutta P, Thakur JS, SachdevaN, Bhadada SK, Walia R. Utility of Glycated Hemoglobin inDiagnosing Type 2 Diabetes Mellitus: A Community-Based Study. J ClinEndocrinol Metab. 2010, 95:2832-5.

159.      *Sachdeva N, WeinsteinJE, Ashman M, Sachdeva M, Brewer TH, Garcia D, Asthana D. Impaireddifferentiation of memory CD8 T cells following stimulation with HIV-1 Gag p24in HIV-1 infected patients with immunological and virological discordance. Viral Immunol. 2010, 23:49-61.

160.     Sachdeva M, Fischl MA, Pahwa R, Sachdeva N, Pahwa S. Basic andTranslational Science Immune Exhaustion Occurs Concomitantly With ImmuneActivation and Decrease in Regulatory T Cells in Viremic ChronicallyHIV-1-Infected Patients. JAIDS: Journal of Acquired Immune DeficiencySyndromes. 2010, 54: 447-54.

161.     Bhansali A, Upreti V, Khandelwal N, Marwaha N, Gupta V, Sachdeva N,Sharma RR, Saluja K, Dutta P, Walia R, Minz R, Bhadada S, Das S, RamakrishnanS. Efficacy OfAutologous Bone Marrow Derived Stem Cell Transplantation In Patients With Type2 Diabetes Mellitus. Stem Cells Dev. 2009, 18:1407-16.

162.      *Sachdeva N,Asthana V, Brewer TH, Garcia D and Asthana D. Impaired restoration ofplasmacytoid dendritic cells in HIV-1 infected patients with poor CD4 T cellreconstitution is associated with decrease in capacity to produce IFN-α but notproinflammatory cytokines. J Immunol.2008, 181: 2887-97.

163.      *Sachdeva, N,Ashman, M, Weinstein, J, Brewer, T, Garcia, D, & Asthana, D. OR. 11.Requirement of CD4 T Cell Help for Maintenance of Protective Memory CD8 T CellResponses: Analysis in HIV-1 Infected Patients with Immunological andVirological Discordance. ClinicalImmunology 2008, 127: S7-S8.

164.      *Sachdeva N,Oshima K, Cotter A, Ashman M, Davila L, Scott G, Okazaki T, Inaba N and AsthanaD. Analysis of Immunological Markers Associated with Pregnancy and HIV-1Infection: Relevance in Predicting Perinatal Transmission in HIV-1 InfectedPregnant Women with Low Plasma Viral Load. AmJ Reprod Immunol. 2008, 60:264-73.

165.     Arora SK, GuptaS, Bhardwaj S, Sachdeva N and Sharma NL. An epitope-specific PCR test fordiagnosis of Leishmania donovani infections. Trans R Soc Trop Med Hyg.2008; 102:41-5.

166.      *Sachdeva N and Asthana D. Cytokine Quantitation:Technology and Applications. Review article (Invited review). Front Biosci. 2007, 12: 4682-95.

167.      *Sachdeva N, Yoon HS,Oshima K, Garcia D, Goodkin K and Asthana D. Biochip array based analysis ofplasma cytokines in HIV patients with immunological and virologicaldiscordance. Scand J Immunol. 2007,6: 549-54.

168.      Ashman M*, Sachdeva N*,Davila L, Scott G, Mitchell C, Cintron L, Rathore M and Asthana D. Influence of4- and 6- color flowcytometers and acquisition/analysis softwares on thedetermination of lymphocyte subsets in HIV infection. Cytometry B: Clin Cytom. 2007;72:380-6. *Equal Contribution.

169.      *SachdevaN, Sehgal S & Arora SK. Prevalenceof drug resistant variants of HIV-1 coexistent with wild type in Indianpatients. J Int AIDS Soc. 2005 Jul 27; 7(3):68. Featured article. Med Gen Med. 2005, 7:68. http://www.medscape.com/viewarticle/506942.

170.     *Sachdeva N, Sehgal S, Sud A, Datta U, Arora SK. Incidenceof lamivudine resistance associated mutations in pol-gene of HIV-1 in patientsfrom north India: a preliminary report. Indian J Pathol Microbiol. 2005; 48:337-40.

171.     Girish V, Sachdeva N, Minz RW, Radotra B, Mathuria SN, Arora SK. Bcl2 and ROS1 expression in humanmeningiomas: an analysis with respect to histological subtype. Indian J Pathol Microbiol. 2005; 48:325-30.

172.     Gupta V, GuptaA, Sachdeva N, Arora S, BamberyP. Successful management of tubercularsubretinal granulomas. OculImmunol Inflamm. 2006; 14:35-40.

173.     Gupta V, GuptaA, Arora SK, Sachdeva N & Bambrey P. Simultaneous choroidalgranuloma and epididymo-orchitis caused by M.tuberculosis. Am J Ophthalmol. 2005,140: 310-2.

174.     Tiwari RP, SachdevaN, Hoondal GS, Grewal JS. Adaptive acid tolerance response inSalmonella enterica serovar Typhimurium and Salmonella enterica serovar Typhi. J BasicMicrobiol. 2004; 44:137-46.

BOOK CHAPTERS

1.      Badal D, PaulM, Jacob N, Sachdeva N*. Microbiome and Cellular Players in Type-1 Diabetes:From Pathogenesis to Protection. In Advanced Concepts in Human Immunology: Prospects for DiseaseControl, 161-227,2020. Editors – Pooja Jain and Lishomwa C. Ndhlovu. Springer Nature Publishing,AG Cham. (Invited Chapter). ISBN: 978-3-030-33945-3.

2.      Arya AK, *Sachdeva N. PTHassays and applications to bone disease: an overview on methodology. Biomarkers in Bone Disease: Methods,Discoveries and Applications. Series Editor - Victor Preedy. (InvitedChapter). Springer Publishing, UK.

3.     Asthana D, FischlM, Sachdeva N, Teppler H, Sinnot JT and Weinhold KJ. HostResponse (Chapter 3). In, InternationalAtlas of AIDS. 4rth Ed. 2008. Series Editor - Gerald L. Mandell, Editor- Donna Mildvan, Current Medicine, LLC (Springer), Philadelphia, USA.

PATENTS

1.    Multiplex PCR assay for detection of Mycobacterium tuberculosis, Toxoplasma gondii,Cytomegalovirus (CMV) and pathogenically important fungi. US Patent No. 7,504,494 dated 17 Mar 2009.