Dr. Neelam Taneja
Designation : Professor
Department : MEDICAL MICROBIOLOGY
taneja.neelam@pgimer.edu.in

 

 
 :: Contact Details
  Phone No.    :   7087008160
  Ext No.        :   5160
 :: Educational Qualification
  Graduation :   MBBS from Lady Harding Medical college Delhi in year 1988
  Post Graduation :   MD Microbiology from Lady Harding Medical college Delhi in year 1995
  Other Qualification.(1)      :   FIMSA in year 2009
  Other Qualification.(2)      :   Dip Vaccinology (Pasteur Institute, Paris) from Pasteur Institute Paris in year 2011
     
 :: Area of Interest
       Area Of Interest       :

Enteric infections

  1. Using whole genome sequencing to understand the epidemiology, molecular mechanisms, evolution and genomics of antimicrobial resistance in uropathogens and food borne pathogens, AMR in the environment
  2. Surveillance of community acquired diarrhea and investigation of water and foodborne outbreaks of gastroenteritis
  3. Choleraecology , surveillance and pathogenicity of viable but non-culturable state of V.cholerae
  4. Food borne pathogens: studying the human -zoonotic interphase of campylobacteriosis, salmonellosis and E coli 
  5. Shigella: vaccine, immunology and study of host-parasite interactions, new model
  6. Gut micro biotaand its role in health and disease
  7. Enterotoxigenic Ecoli:Epidemiology, ecology, colonization factor analysis, Multi-locus enzyme electrophoresis
  8. Urinary tract and hospital acquired infections
     
 :: Research & Projects
      Extramural Projects       :

2019-21 Wellcome trust-UK  Understanding the nature and diversity of Vibrio cholerae at its global source

2019-21 DBT A cocktail of phages effective against urinary tract infections caused by biofilm forming MDR uropathogenic E.coli

2019-20 WHO: ESBL-EC Tricycle project India

2012-16 WHO-AGISAR Monitoring the Antimicrobial Resistance Profile of Bacterial Food-borne Pathogens in Humans, Food Animals and Retail Meat in India.

2015-2018 ICMR-Colonization factor analysis and molecular epidemiology of  Enterotoxigenic E. Coli.

2009-2012 ICMR Molecular mechanisms and epidemiology of antimicrobial resistance in Shigella over a decade

2008-11 ICMR Prevalence, characterization and epidemiological typing of Shiga toxin producing   Escherichia coli isolated from meat products, unpasteurised milk, cattle and children in north India.

2017-2020 DST Animal challenge study of novel Shigella vaccine antigens common to multiple serotypes.

2013-17 ICMR A study of serotypic differences in innate and adaptive immune responses in shigellosis in human.

WHO Phase 1 (2008-09) , phase 2 (2011)Strengthening district public health laboratories for laboratory surveillance of communicable diseases of outbreak potential,

2017-21 ICMR-AIIMS-CDC India Collaborative Project :Capacity Building and Strengthening of Hospital Infection Control to detect and prevent antimicrobial resistance in India

 

2019 PHFI Project:Antimicrobial resistance and zoonotic transmission in enteric bacteria at human and animal interface in an intensive food production geographic area


2019-21 DST Chandigarh study:Assessing bacteriological safety of drinking water and detection of waterborne bacterial pathogens from source of supply to point of use, by conventional and molecular assays in Manimajra, Chandigarh.


2019-20 Intramural project:A prospective observational study of the intestinal colonization, change in the colonization pattern and risk factors for colonization and infection with Diarrhoeagenic E. coli in the neonatal intensive care unit of PGIMER 

      Departmental / P.G.I.
      Projects      
:
  1. Genome Sequencing  of Escherichia Phage PGN829.1, Active against Highly Drug-Resistant Uropathogenic Escherichia coli
  1. Emergence of epidemic clone of Salmonella Kentucky ST198 and its potential of zoonotic transmission, India.
  2. AmpC mediated cephalosporin resistant Salmonella Typhi since 2001, India.
  3. Biocontrol of cholera using Vibrio phage Vmj1 in fresh water microcosm of North India.
  4. Diversity of food-borne pathogens and their antimicrobial resistance in food animals from the largest surveillance study, India.
  5. Comparative analysis of virulence determinants, phylogroups and antibiotic susceptibility pattern of atypical Enteroaggregative Escherichia coli versus typical Enteroaggregative E. coli in India
  6. Evaluation of Risk Factors for Colistin Resistance among Uropathogenic Isolates of E. coli and K. pneumoniae: A Case-Control Study.
  7. Nontyphoidal Salmonella at human -animal interface, AMR and transmission dynamics
  8. Pathogenic Escherichia coli among malnourished children aged less than 5 years – a case control study  
  9. Prevalence and virulence gene profiling of Enteroaggregative Escherichia coli in malnourished and nourished children without diarrhea
  10. A one health approach to study the epidemiology and transmission of antimicrobial resistance Salmonella and other Enterobacteriaceae in North  India.
  11. Identification of drug targets in Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis.
  12. Identification of novel inhibitors against E. coli utilizing HisC as a target from histidine biosynthesis pathway.
  13. EAEC as causative agents of chronic diarrhea-a prospective evaluation
  14. Understanding the genomic profile of pan drug resistant uropathogenic Klebsiella pneumoniae causing complicated urinary tract infection.
  15. Isolation, characterization and AMR in Campylobacter isolated from community acquired diarrhea
      Research In
      Progress      
:
  1. A study to find a common immunodominant antigen in shigellae by reverse vaccinology (ICMR  International patent on novel immunodominant antigens of shigellae )
  2. A study of serotypic differences in innate and adaptive immune responses in shigellosis in human (ICMR)
  3. Colonization factor analysis and molecular epidemiology of Enterotoxigenic E. coli (ICMR)
  4. Integrated Surveillance of Antimicrobial Resistance (AGISAR) for foodborne pathogens(WHO Indo-US)
  5. Strengthening district public health laboratories for laboratory surveillance of communicable diseases of outbreak potential, Phase 1 (2008-09) , phase 2 (WHO)
  6. Laboratory training of microbiologists of district public health laboratories communicable diseases of outbreak potential (WHO)
  7. Molecular mechanisms and evolution of antimicrobial resistance in nontyphoidal salmonellae, shigellae and diarrhoegenic E. coli
  8. Epidemiology and drug resistance in community-acquired urinary tract infections
  9. Study of zoonotic interphase between human campylobacteriosis and poultry
  10. Evaluation of rapid diagnostic field  assays for shigellosis, Vibrio cholerae, Shigatoxigenic E. coli
  11. Virulence potential of VBNC state of Vibrio cholerae
      Area Of
      Specialization      
:

  1. Diarrhoea
  2. UTI
  3. Hospital acquired infection (HAI)
      Future Plans       :
      Awards & Honours       :

2008-International Development award for young woman scientist-ISID

2009 -Fellow of International Medical Sciences Academy

2012-WHO fellowship on antimicrobial resistance

2011-Pasteur Institute,Paris Fellowship on vaccinology

2016,2018- Wellcome Research  Institute Fellowship

2016: ASM CME award on AMR

2014-ESCMID fellowship on AMR

2017-IAMM best published paper in Bacteriology

2013-Institute Research award for publishing high quality research paper

2012, 2017 -ICMR international travel awards

2009,2010,2011,2014,2017-NIH travel fellowship awards

2004,2009,2014,2016-Best paper awards at Gastroenterology conferences, MICROCON, ISID

2019: Bill and Melinda Gate Foundation to attend 53rd United States-Japan Cooperative Joint Medial Science Program’s Joint Panel conference on Cholera and other bacterial enteric infections from Feb 26th to 2nd March, 2019 at Hanoi, Vietnam.

2016, 2018 : PATH travel award to attend   International VASE Conference on Vaccines against Shigella and ETEC  

      2019 :Hindi award by Director, PGIMER, for using Hindi language in daily work.

      Member Of Professional
      Bodies      
:
  • Member of Strategic partnership UK research
  • Expert Member of National action plan of India on AMR
  • Expert to Centre for Science and Environment, Delhi
  • Scientific advisory board member of NICED Kolkata
  • External expert for ICMR fellowship and extramural grants
  • Strengthened the microbiological capacity of  10 district public health laboratories in Punjab, Haryana and Uttarakhand to diagnose communicable diseases of outbreak potential through WHO iniated activity
  • Contributor to National Board of Examination (DNB) and examiner for many universities
  • National trainer for Microbiologists under the IDSP (Integrated Disease surveillance Programme)
  • Invited by WHO as a national consultant for strengthening laboratory capacity for diagnosis of infectious diseases (IDSP) on 12-13th May 2010
  • Elected fellow of International Medical Sciences Academy in recognition of outstanding contribution to advancement of medical sciences in 2009 .
  • Executive Council  and Editorial board member of Gastrointestinal Infections Society of India.
  • Secretary, Society of South Asian Countries Society for Prevention of Healthcare Associated Infection
  • Scientific secretary MICROCON 2016
  • Organising secretary, National workshop on 23rd Nov 2016 entitled Investigation of Foodborne Infections.
  • Organising secretary WHO –PGI workshop on laboratory training on communicable diseases of outbreak potential at District level , July 2009,Phase II –May 2011
  • Organising secretary, Workshop cum CME on Sterilisation and disinfection procedures, 2006.
     
 :: Publications(In Vancouver Style)


Publications:157, patent One

H-index 26;  i-10 index -62

Important publications

1.     Taneja N, Pahil S,Sharma M.International patent :Novel immunogenic antigens common to Shigella            INPCT/IN2013/000703            2013-11-19.

2.     Mahindroo J, Thanh DP, Nguyen TNT, Mohan B, Thakur S, Baker S, TanejaN.Endemicfluoroquinolone-resistant Salmonellaenterica serovar Kentucky ST198 in northernIndia.Microb Genom. 2019 Jun 5. doi:0.1099/mgen.0.000275. [Epub ahead of print

3.     Kaza P, Mahindroo J, Veeraraghavan B, Mavuduru RS, Mohan B, TanejaN.Evaluation ofrisk factors for colistin resistance among uropathogenic isolates ofEscherichia coli and Klebsiella pneumoniae: a case-control study. J Med Microbiol. 2019 Jun;68(6):837-847. doi: 10.1099/jmm.0.000986.Epub 2019 May 14

4.     Chaudhary N, Mohan B, Taneja N.Draft Genome Sequence of Escherichia PhagePGN829.1, Active against Highly Drug-Resistant Uropathogenic Escherichia coli.Microbiol Resour Announc. 2018 Nov 21;7(20). pii:e01141-18. doi: 10.1128/MRA.01141-18. eCollection 2018 No

5.     SharmaAP, Devana SK, Bora GS, Mavuduru RS, Mohan B, Taneja N, Singh SK,Mandal AK Protocol-basedperioperative antimicrobial prophylaxis in urologic surgeries: Feasibility andlessons learned. Indian J Urol. 2019Apr-Jun;35(2):141-146. doi: 10.4103/iju.IJU_270_1

6.     Taneja N, Sharma M.scenario. Indian J Med Res. 2019 Feb;149(2):119-128. doi: 10.4103/ijmr.IJMR_331_18.Review

7.     Pahil S, Taneja N, Ansari HR,Raghava GPS.In silico analysisto identify vaccine candidates common to multiple serotypes of Shigella andevaluation of their immunogenicity. PLoS One. 2017Aug 2;12(8):e0180505. doi: 10.1371/journal.pone.0180505. eCollection 2017.PMID:28767653

8.    Kumar A, Taneja N,Sharma M. An epidemiological and environmental study of Shiga toxin-producingEscherichia coli in India. Foodborne Pathog Dis. 2014 Jun; 11(6):439-46.

9.     Kumar A, Taneja N,Sharma RK, Sharma H, Ramamurthy T, Sharma M. Molecular characterization ofShiga-toxigenic Escherichia coli isolated from diverse sources from India bymulti-locus variable number tandem repeat analysis (MLVA). Epidemiol Infect.2014 Dec; 142(12):2572-82

10. Shewade HD, Patro BK, Bharti B, Soundappan K, Kaur A, TanejaN. Effectivenessof Indigenous Ready-to-Use Therapeutic Food in Community-based Management ofUncomplicated Severe Acute Malnutrition: a Randomized Controlled Trial fromIndia.J Trop Pediatr. 2013 Oct;59(5):393-8.

11.  Malvi S, Appannanavar S, Mohan B,Kaur H, Gautam N, Bharti B, Kumar Y, Taneja N. Comparative analysis ofvirulence determinants, antibiotic susceptibility pattern and serogrouping ofatypical enteropathogenic E. coliversus typical enteropathogenic E. coliin India. J Med Microbiol. 2015 Jul30. doi: 10.1099/jmm.0.000131. [Epub ahead of print]

12. TanejaN, Mishra A, Kumar A, Verma G, SharmaM. Enhanced resistance to fluoroquinolones in laboratory-grown mutants &clinical isolates of Shigella due to synergism between efflux pump expression& mutations in quinolone resistance determining region. Indian J Med Res. 2015 Jan;141(1):81-9.

13.  Taneja N, Appannanavar SB, Kumar A, Varma G, Kumar Y, Mohan B,Sharma M. Serotype profile and molecular characterization of antimicrobialresistance in non-typhoidal Salmonella isolated from gastroenteritis cases overnine years. J Med Microbiol. 2014Jan;63(Pt 1):66-73. doi: 10.1099/jmm.0.061416-0. Epub 2013 Oct 22.

14. J.Mahindroo, I. Shyam, B. Mohan, S. Thakur, N.Taneja. “Cronobactersakazakii - An unrecognised food borne pathogen, India”. International Journal ofInfectious Diseases 2016; 45:182. DOI:10.1016/j.ijid.2016.02.426.

15.  Parakriti, Balvinder Mohan, AjayKumar, Garima Varma, Abhishek Mewara NeelamTaneja. “Fluoroquinoloneresistance in Shigella over a decade In India: Do we have Plasmid-mediatedquinolone resistance?” International Journal of InfectiousDiseases 2016; 45:175. DOI: 10.1016/j.ijid.2016.02.412.

16.  Balvinder Mohan, Amber Prasad, Harsimran Kaur,Vinaykumar Hallur, Neha Gautam, NeelamTaneja. “Fecal carriage of carbapenem resistant Enterobacteriaceae (CRE) and risk factor analysis in hospitalizedpatients: a single centre study from India”. International Journal of Infectious Diseases 2016; 45:103.DOI:10.1016/j.ijid.2016.02.268.

17.  Duran C, Nato F,Dartevelle S, Thi Phuong LN, Taneja N, Ungeheuer MN, Soza G,Anderson L, Benadof D, Zamorano A, Diep TT, Nguyen TQ, Nguyen VH, Ottone C,Bégaud E, Pahil S, Prado V, Sansonetti P, Germani Y.Rapid diagnosis of diarrhea caused by shigella sonnei usingdipsticks; comparison of rectal swabs, direct stool and stool culture. PLoS One. 2013 Nov 22;8(11):e80267. doi:10.1371/journal.pone.0080267. eCollection 2013.

18.  Taneja N, Mewara A, Kumar A,Verma G, Sharma M. Cephalosporin-resistant Shigellaflexneri over 9 years (2001-09) in India. J Antimicrob Chemother. 2012 Mar 12  Jun;67(6):1347-53.

19. KumarA, Taneja N, Kumar Y, Sharma M. Detectionof Shiga toxin variants among Shiga toxin-forming Escherichia coli isolatesfrom animal stool, meat and human stool samples in India. J Appl Microbiol. 2012 Nov; 113(5):1208-16.

20.  Taneja N, Appananavar SB, Kumar A, VarmaG, Kumar Y, Mohan B, Sharma M. Serotype profile andmolecular characterization of antimicrobial resistance in non-typhoidal Salmonella isolatedfrom gastroenteritis cases over nine years, India. J Med Microbiol. 2014 Jan; 63(1):66-73.

21.  Dikid T,Hpalya SS, Thakur JS, Taneja N, Thapar R, Kumar R. Salmonella foodpoisoning outbreak in Kharar town of Panjab. Indian J Public Health2009; 53: 265

22.  Chandra BK,Singh G, Taneja N, Pahil S, Singhi S, Sharma M. Diarrhoeagenic E. colias predominant cause of paediatric nosocomial diarrhoea in India. J MedMicrobiol. 2012 Jun; 61(Pt 6):830-6.

23.  Taneja N, Singh G, Singh M,Madhup S, Pahil S, Sharma M .Highoccurrence of blaCMY-1 AmpC lactamase producing Escherichia coli in cases of complicated urinary tract infection(UTI) from a tertiary health care centre in north India. Indian J Med Res. 2012Aug;136(2):289-91.

24.  Taneja N,SinghM,RaoP,BiswalM,PriyaS,ChanderR,SharmaM.Fecalcontamination of drinking water supplies in and around Chandigarh andcorrelation with acute gastroenteritis. J Commun Dis.2011 Sep; 43(3):193-9.

25.  Biswal M, Khurana S, Taneja N, Kaur T, Samanta P, Malla N, SharmaM. Is routine medical examination of food handlers enoughto ensure food safety in hospitals? J Commun Dis. 2012 Sep; 44(3):139-44.

26.  Mishra A, Taneja N, Sharma M. Viability kinetics,induction, resuscitation and quantitative real-time polymerase chain reaction analysesof viable but nonculturable Vibriocholerae O1 in freshwater microcosm. JAppl Microbiol. 2012 Feb 11. doi: 10.1111/j.1365-2672.2012.05255.x.

 

27.  Mishra A, Taneja N,Sharma M. Environmental and epidemiological surveillance of Vibrio cholerae ina cholera-endemic region in India with freshwater environs. J Appl Microbiol. 2012Jan;112(1):225-37. doi: 10.1111/j.1365-2672.2011.05191.x. Epub 2011 Nov 29.

28.  Taneja N, Nato F, Dartevelle S,Sire JM, Garin B, Thi Phuong LN, Diep TT, Shako JC, Bimet F, Filliol I, MuyembeJJ, Ungeheuer MN, Ottone C, Sansonetti P, Germani Y. Dipstick test for rapiddiagnosis of Shigella dysenteriae 1 in bacterial cultures and its potential useon stool samples. PLoS One.2011;6(10):e24830. Epub 2011 Oct 3.

29.  Mishra A, Taneja N, SharmaRK, Kumar R, Sharma NC, Sharma M. Amplified fragment length polymorphism ofclinical and environmental Vibriocholerae from a freshwater environment in a cholera-endemic area, India. BMC Infect Dis. 2011 Sep 22;11:249

 

30.  TanejaN, Mishra A, Sangar G, Singh G,Sharma M. Outbreaks caused by new variants of Vibrio cholerae O1 El Tor, India. Emerg Infect Dis. 2009 Feb;15(2):352-4

31. TanejaN, Kaur H. Insights into NewerAntimicrobial Agents Against Gram-negative Bacteria. MicrobiolInsights. 2016 Mar 20;9:9-19. doi:10.4137/MBI.S29459. eCollection 2016. Review

32.  Taneja N, Singh G, Singh M,Madhup S, Pahil S, Sharma M. High occurrence ofblaCMY-1 AmpC lactamase producing Escherichia coli in cases of complicatedurinary tract infection (UTI) from a tertiary health care centre in north India..Indian JMed Res. 2012 Aug;136(2):289-91

33. Chandra BK,Singh G, Taneja N, Pahil S, Singhi S, Sharma M. Diarrhoeagenic E. colias predominant cause of paediatric nosocomial diarrhoea in India. J MedMicrobiol. 2012 Mar 1.

34.  Taneja N, Chari P, Singh M, Singh G, BiswalM, Sharma M Evolution of bacterial flora in burn wounds: key role ofenvironmental disinfection in control of infection. Int J Burns Trauma. 2013Apr 18;3(2):102-7. Print 2013

35.  SinghM, Sharma R, Gupta PK, Rana JK, Sharma M, Taneja N.Comparative efficacyevaluation of disinfectants routinely used in hospital practice: India.IndianJ Crit Care Med. 2012 Jul;16(3):123-9. doi: 10.4103/0972-5229.102067.

36.  Mishra A, Taneja N, Sharma M.Demonstration of viable but nonculturable Vibrio cholerae O1 in fresh waterenvironment of India using ciprofloxacin DFA-DVC method.Lett Appl Microbiol.2011 Jul;53(1):124-6. doi: 10.1111/j.1472-765X.2011.03077.x. Epub 2011 May31  Im factor 1.647/2